2-chloro-6-(trifluoromethyl)pyridine-3-carbonitrile

2-chloro-6-(trifluoromethyl)pyridine-3-carbonitrile - Names and Identifiers

Name	2-Chloro-6-trifluoromethyl-nicotinonitrile
Synonyms	2-Chloro-6-(trifluoromethyl)nicot hloro-6-(trifluoromethyl)nicotinonitrile 2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINITRILE 2-Chloro-6-trifluoromethyl-nicotinonitrile 2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINONITRILE 2-Chloro-6-(trifluoromethyl)nicotinonitrile 2-chloro-6-(trifluoromethyl)pyridine-3-carbonitrile 2-chloro-6-(trifluoromethyl)-3-pyridinecarbonitrile 3-Pyridinecarbonitrile, 2-chloro-6-(trifluoromethyl)- 2-Chloro-6-(trifluoromethyl)pyridine-3-carbonitrile, 2-Chloro-3-cyano-6-(trifluoromethyl)pyridine
CAS	386704-06-9 389117-37-7
InChI	InChI=1/C7H2ClF3N2/c8-6-4(3-12)1-2-5(13-6)7(9,10)11/h1-2H

2-chloro-6-(trifluoromethyl)pyridine-3-carbonitrile - Physico-chemical Properties

Molecular Formula	C7H2ClF3N2
Molar Mass	206.55
Density	1.51±0.1 g/cm3(Predicted)
Melting Point	37～38℃
Boling Point	74～76℃/1mb
Flash Point	96.014°C
Vapor Presure	0.051mmHg at 25°C
pKa	-6.61±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.483

2-chloro-6-(trifluoromethyl)pyridine-3-carbonitrile - Introduction

It is an organic compound with the chemical formula C7H2ClF3N. It is a colorless to pale yellow crystal with a pungent odor.

widely used in the synthesis of pesticide intermediates. It can be used as a raw material for the manufacture of a variety of pesticides such as imidacloprid, the herbicide variety quinalone, etc. In addition, it can also be used as an intermediate for the synthesis of new drugs and bioactive molecules, such as anticancer drugs.
The preparation method of
is generally obtained by reacting 2-chloro-6-trifluoromethylpyridine with chlorocyanin. The specific steps include dissolving 2-chloro-6-trifluoromethylpyridine and chlorocyanin in a suitable solvent, adding a corresponding catalyst, and heating the reaction for a period of time to obtain the product.

Regarding safety, irritant, contact with skin or inhalation may cause irritation and discomfort. Appropriate protective measures should be taken during operation, such as wearing protective gloves, goggles and respiratory protection. Avoid contact with oxidants, strong acids, strong bases and other substances during storage and handling to prevent dangerous reactions.

Last Update：2024-04-09 21:54:55