2-chloro-N-methoxy-N-methylacetamide
2-chloro-N-methoxy-N-methylacetamide
CAS: 67442-07-3
Molecular Formula: C4H8ClNO2
2-chloro-N-methoxy-N-methylacetamide - Names and Identifiers
| Name | 2-chloro-N-methoxy-N-methylacetamide |
| Synonyms | 100823 2-chloro-N-methoxy-N-methylacetamide N-Methyl-N-methoxy-2-chloroacetamide 2-CHLORO-N-METHOXY-N-METHYLACETAMIDE 2-Chloro-N-methoxy-N-methylacetamide N-(Chloroacetyl)-N-methoxymethylamine AcetaMide, 2-chloro-N-Methoxy-N-Methyl- Acetamide, 2-chloro-N-methoxy-N-methyl- Methyl 2-Chloro-N-methylacetohydroxamate |
| CAS | 67442-07-3 |
| InChI | InChI=1/C4H8ClNO2/c1-6(8-2)4(7)3-5/h3H2,1-2H3 |
| InChIKey | SCOJKGRNQDKFRP-UHFFFAOYSA-N |
2-chloro-N-methoxy-N-methylacetamide - Physico-chemical Properties
| Molecular Formula | C4H8ClNO2 |
| Molar Mass | 137.56 |
| Density | 1.178±0.06 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 39-41°C(lit.) |
| Boling Point | 94-95 °C |
| Flash Point | 220°F |
| Water Solubility | Insoluble in water. |
| Vapor Presure | 5.83mmHg at 25°C |
| Appearance | Crystals |
| Color | White to light yellow |
| BRN | 1924015 |
| Storage Condition | 2-8°C |
| Refractive Index | 1.442 |
| MDL | MFCD00134232 |
2-chloro-N-methoxy-N-methylacetamide - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S23 - Do not breathe vapour. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S28 - After contact with skin, wash immediately with plenty of soap-suds. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| HS Code | 29241900 |
2-chloro-N-methoxy-N-methylacetamide - Introduction
It is an organic compound with the chemical formula C5H10ClNO2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: Usually colorless to yellowish liquid.
-Melting point and boiling point: The melting point of the compound is about -1°C, and the boiling point is about 147°C.
-Solubility: It has low solubility in water and high solubility in common organic solvents.
-Chemical properties: This is a compound with electrophilicity, which can undergo chemical reactions through electrophilic substitution reactions.
Use:
-is often used as a reagent and intermediate in organic synthesis, especially for the synthesis of various amino acid derivatives and pharmaceutical intermediates.
-This compound is also widely used in dyes, pigments, pesticides and other organic synthesis reactions.
Preparation Method:
It can be synthesized by the following steps:
1. methoxy acetamide and basic bromide reaction, generate the corresponding bromo amide.
2. Bromo amide reacts with carbon monoxide and methanol to form the corresponding methanol amide.
3. Methanol reacts with liquid ammonia or methylamine to obtain the final product, namely amide.
Safety Information:
-However, it generally has low toxicity under normal operating conditions, but it is still necessary to pay attention to safe operation to avoid contact and inhalation.
-Avoid direct contact with skin and eyes and wear appropriate protective gloves and goggles if necessary.
-When handling this substance, maintain a well-ventilated laboratory environment and avoid inhaling its vapor or gas.
-If inhaled or exposed to the substance, clean the affected area immediately and seek medical help if needed.
Nature:
-Appearance: Usually colorless to yellowish liquid.
-Melting point and boiling point: The melting point of the compound is about -1°C, and the boiling point is about 147°C.
-Solubility: It has low solubility in water and high solubility in common organic solvents.
-Chemical properties: This is a compound with electrophilicity, which can undergo chemical reactions through electrophilic substitution reactions.
Use:
-is often used as a reagent and intermediate in organic synthesis, especially for the synthesis of various amino acid derivatives and pharmaceutical intermediates.
-This compound is also widely used in dyes, pigments, pesticides and other organic synthesis reactions.
Preparation Method:
It can be synthesized by the following steps:
1. methoxy acetamide and basic bromide reaction, generate the corresponding bromo amide.
2. Bromo amide reacts with carbon monoxide and methanol to form the corresponding methanol amide.
3. Methanol reacts with liquid ammonia or methylamine to obtain the final product, namely amide.
Safety Information:
-However, it generally has low toxicity under normal operating conditions, but it is still necessary to pay attention to safe operation to avoid contact and inhalation.
-Avoid direct contact with skin and eyes and wear appropriate protective gloves and goggles if necessary.
-When handling this substance, maintain a well-ventilated laboratory environment and avoid inhaling its vapor or gas.
-If inhaled or exposed to the substance, clean the affected area immediately and seek medical help if needed.
Last Update：2024-04-09 19:05:52
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Product Name: 2-Chloro-N-methoxy-N-methylacetamide Visit Supplier Webpage Request for quotationCAS: 67442-07-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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