2-chlorobenzene-1,3-diol

Name	2-Chloro-1,3-dihydroxybenzene
Synonyms	2-Chlorresorcine 2-CHLORORESORCINOL 2-Chlororesorcinol 2-Chloro Resorcinol 2-Chlorobenzene-1,3-diol 2-chlorobenzene-1,3-diol 2,6-DIHYDROXYCHLOROBENZENE 2,6-Dihydroxychlorobenzene 2-Chloro-1,3-dihydroxybenzene 2-Chloro-1,3-dihydroxybenzene, 2-Chlorobenzene-1,3-diol
CAS	6201-65-6
EINECS	228-256-0
InChI	InChI=1/C6H5ClO2/c7-6-4(8)2-1-3-5(6)9/h1-3,8-9H
InChIKey	SWZVJOLLQTWFCW-UHFFFAOYSA-N

Molecular Formula	C6H5ClO2
Molar Mass	144.56
Density	1.471±0.06 g/cm3(Predicted)
Melting Point	94-99°C
Boling Point	244.1±20.0 °C(Predicted)
Flash Point	101.4°C
Vapor Presure	0.0198mmHg at 25°C
pKa	7.98±0.10(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.629
Use	Used as pharmaceutical, pesticide intermediates

Hazard Symbols	Xn - Harmful
Risk Codes	R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
WGK Germany	3

introduction	2-chloro -1,3-hydroquinone is a white solid, density: 1.471g/cm3, boiling point: 244.1°C at 760 mmHg, melting point: 94-99 c.
preparation	add 30 mL dichloromethane into a dry round bottom flask filled with anhydrous aluminum trichloride (2. 6g,20 mmol) and resorcinol (1. 1g,10 mmol), seal the bottle mouth with a rubber stopper equipped with a nitrogen balloon, add phosphorus oxychloride (0. 72 ml,10 mmol) under the ice bath through a needle tube with a rubber stopper, and control the addition time to be about 90 minutes. Ice bath reaction, after stirring for 5 h, TLC spot plate tracking, the developing agent (dichloromethane: methanol = 97: 3/volume ratio) was observed under the ultraviolet lamp 254nm . Stop the reaction, spin the solution to dry, add 2N hydrochloric acid 15 mL under ice bath, then add ethyl acetate 200mL for extraction, dry the organic layer with anhydrous magnesium sulfate after separation, filter, spin dry to obtain light yellow solid, column chromatography, eluent (dichloromethane: methanol = 97: 1. 5), collect, spin dry to obtain 2-chlorine -1,3-hydroquinone.
use	used as pharmaceutical and pesticide intermediates pharmaceutical intermediates.

Last Update：2024-04-09 21:11:58

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2-chlorobenzene-1,3-diol

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