2-chloroflumethasone

Name	2-Chloroflumethasone
Synonyms	Sicorten HALOMETASONE Halometasone Halomethasone HALOMETASONE HYDRATE 2-Chloroflumethasone 2-chloroflumethasone HALOMETASONE MONOHYDRATE 2-chlor-6a,9-difluor-11b,17,21-trihydroxy-16a-methyl-1,4-pregnadien-3,20-dion (6alpha,11beta,16alpha)-2-chloro-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione (6alpha,11beta,14xi,16alpha)-2-chloro-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
CAS	50629-82-8
EINECS	256-664-9
InChI	InChI=1/C22H27ClF2O5/c1-10-4-11-12-5-15(24)13-6-16(27)14(23)7-19(13,2)21(12,25)17(28)8-20(11,3)22(10,30)18(29)9-26/h6-7,10-12,15,17,26,28,30H,4-5,8-9H2,1-3H3/t10-,11+,12+,15+,17+,19+,20+,21+,22+/m1/s1

Molecular Formula	C22H27ClF2O5
Molar Mass	444.9
Density	1.42±0.1 g/cm3(Predicted)
Melting Point	220-222° (dec)
Boling Point	600.5±55.0 °C(Predicted)
Flash Point	316.994°C
Solubility	Acetone (Sparingly), DMSO (Slightly), Methanol (Slightly)
Vapor Presure	0mmHg at 25°C
Appearance	Solid
Color	White to Off-White
pKa	11.93±0.70(Predicted)
Storage Condition	Refrigerator
Refractive Index	1.586
Physical and Chemical Properties	Melting point 220~222 ℃ (decomposition).

introduction	halometasone belongs to hormone drugs. it is a glucocorticoid hormone, and its main functions are anti-allergy, vasoconstriction, anti-proliferation and anti-inflammatory. It is often used to treat various non-infectious dermatitis, such as atopic dermatitis, seborrheic dermatitis, contact dermatitis, psoriasis vulgaris, localized neurodermatitis, coin dermatitis, etc.
side effects	use of halometasone occasionally causes irritant symptoms at the medication site, such as burning sensation and itching pain. Rare: Dry skin, erythema, skin atrophy, folliculitis, acne or pustules. If severe irritation or allergic symptoms have occurred, treatment should be terminated.
chemical properties	melting point 220~222 ℃ (decomposition).
use	topical adrenocortical hormone drugs have significant and rapid anti-inflammatory, anti-allergic, anti-pruritic, anti-exudation and anti-proliferative effects. Suitable for eczema skin diseases and all kinds of mild eczema and subacute dermatitis. Indications: It is used for skin diseases that respond to external adrenal cortex hormones, such as acute or chronic eczema diseases and common psoriasis, which have certain curative effects.
production method	compound (I) first reacts with chlorine to add the double bonds at the 1 and 2 positions, and then under the action of pyridine, hydrogen chloride is removed and double bonds are re-formed at the 1 and 2 positions; then hydrolyzed to obtain halometasone.

Last Update：2024-04-09 21:04:16

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CAS: 50629-82-8
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Multiple Specifications

Product Name: Halometasone Monomer Request for quotation
CAS: 50629-82-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Product Name: Halometasone Visit Supplier Webpage Request for quotation
CAS: 50629-82-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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2-chloroflumethasone

2-chloroflumethasone Request for Quotation