2-chloropyridin-4-carboxaMide
2-chloroisonicotinamide
CAS: 100859-84-5
Molecular Formula: C6H5ClN2O
2-chloropyridin-4-carboxaMide - Names and Identifiers
| Name | 2-chloroisonicotinamide |
| Synonyms | C257 Oprea1_265572 2-CHLOROISONICOTINAMIDE 2-chloroisonicotinamide 2-chloropyridin-4-carboxaMide 2-chloropyridine-4-carboxamide 2-CHLOROPYRIDINE-4-CARBOXAMIDE 6-methyl-5-nitropyridin-2(1H)-one 2-carbaMoyl-2-chloro-1,2-dihydropyridine-4-carboxylic acid |
| CAS | 100859-84-5 |
| InChI | InChI=1/C6H5ClN2O/c7-5-3-4(6(8)10)1-2-9-5/h1-3H,(H2,8,10) |
2-chloropyridin-4-carboxaMide - Physico-chemical Properties
| Molecular Formula | C6H5ClN2O |
| Molar Mass | 156.57 |
| Density | 1.381±0.06 g/cm3(Predicted) |
| Melting Point | 198 °C |
| Boling Point | 312.2±27.0 °C(Predicted) |
| Flash Point | 142.6°C |
| Vapor Presure | 0.000535mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Orange to Green |
| pKa | 14.37±0.50(Predicted) |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.588 |
2-chloropyridin-4-carboxaMide - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Hazard Note | Irritant |
2-chloropyridin-4-carboxaMide - Introduction
2-Chloro-4-carboxamide pyridine, chemical formula C9H6ClNO, is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
2-Chloro-4-carboxamido pyridine is a white crystalline solid which is soluble in organic solvents such as ethanol, acetone and chloroform. It has a lower melting and boiling point.
Use:
2-Chloro-4-carboxamide pyridine is an important intermediate, which is widely used in the field of organic synthesis. It can be used to synthesize organic compounds containing pyridine and amide groups, such as pharmaceuticals, pesticides, dyes and functional polymer materials. It can also be used as a complexing agent for certain metal ions.
Preparation Method:
The preparation of 2-chloro-4-carboxamide pyridine is usually obtained by reacting 2-chloropyridine and formamide under basic conditions. Specific reaction conditions and steps can be adjusted according to actual needs.
Safety Information:
Take the necessary safety precautions when using 2-chloro-4-carboxamide pyridine. It is an organic compound that may cause irritation and damage to the eyes, respiratory tract and skin. Therefore, appropriate protective equipment such as safety glasses, protective gloves and protective masks should be worn during operation. At the same time, make sure to operate in a well-ventilated place to avoid inhaling its vapor. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help.
Nature:
2-Chloro-4-carboxamido pyridine is a white crystalline solid which is soluble in organic solvents such as ethanol, acetone and chloroform. It has a lower melting and boiling point.
Use:
2-Chloro-4-carboxamide pyridine is an important intermediate, which is widely used in the field of organic synthesis. It can be used to synthesize organic compounds containing pyridine and amide groups, such as pharmaceuticals, pesticides, dyes and functional polymer materials. It can also be used as a complexing agent for certain metal ions.
Preparation Method:
The preparation of 2-chloro-4-carboxamide pyridine is usually obtained by reacting 2-chloropyridine and formamide under basic conditions. Specific reaction conditions and steps can be adjusted according to actual needs.
Safety Information:
Take the necessary safety precautions when using 2-chloro-4-carboxamide pyridine. It is an organic compound that may cause irritation and damage to the eyes, respiratory tract and skin. Therefore, appropriate protective equipment such as safety glasses, protective gloves and protective masks should be worn during operation. At the same time, make sure to operate in a well-ventilated place to avoid inhaling its vapor. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help.
Last Update：2024-04-09 21:11:58
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