2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine
cimetidine
CAS: 51481-61-9;2984-61-4
Molecular Formula: C10H16N6S
2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine - Names and Identifiers
| Name | cimetidine |
| Synonyms | Peptol Tratul TAGAMET Tametin Ulcedin SKF-92334 cimetidine Cimetidine A Cimetidine AB Cimetidine (base or and unspecifieds salts) 2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine N-CYANO-N'-METHYL-N''-[[2-[(5-METHYL-1H-IMIDAZOL-4-YL)METHYL]THIO]ETHYL]GUANIDINE |
| CAS | 51481-61-9 2984-61-4 |
| EINECS | 257-232-2 |
| InChI | InChI=1/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14) |
| InChIKey | AQIXAKUUQRKLND-UHFFFAOYSA-N |
2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine - Physico-chemical Properties
| Molecular Formula | C10H16N6S |
| Molar Mass | 252.34 |
| Density | 1.2583 (rough estimate) |
| Melting Point | 139-144°C |
| Boling Point | 476.2±55.0 °C(Predicted) |
| Water Solubility | 0.5 g/100 mL at 20 ºC |
| Solubility | Soluble in methanol or dilute hydrochloric acid, soluble in ethanol, slightly soluble in isopropanol, slightly soluble in water. |
| Appearance | White or white-like crystalline powder |
| Color | White to Off-White |
| Merck | 14,2279 |
| pKa | pKa 6.80 (Uncertain) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.5700 (estimate) |
| MDL | MFCD00133296 |
| Physical and Chemical Properties | Melting point 139-144°C water-soluble 0.5g/100 mL at 20°C |
| Use | For the treatment of peptic ulcer |
2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine - Risk and Safety
| Risk Codes | R60 - May impair fertility R42/43 - May cause sensitization by inhalation and skin contact. R36/37/38 - Irritating to eyes, respiratory system and skin. R20/22 - Harmful by inhalation and if swallowed. |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. S22 - Do not breathe dust. |
| WGK Germany | 3 |
| RTECS | MF0035500 |
| HS Code | 29339900 |
| Toxicity | LD50 in mice, rats (mg/kg): 2600, 5000 orally; 150, 106 i.v.; 470, 650 i.p. (Brimblecombe) |
2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine - Reference
| Reference Show more | 1. [IF=1.627] Yanming Xia et al."Transport mechanism of ursodeoxycholic acid in human placental BeWo cells."Biopharm Drug Dispos. 2018 Jul;39(7):335-343 2. [IF=3.84] Li Qiao et al."Mitochondrial membrane potential played crucial roles in the accumulation of berberine in HepG2 cells."Bioscience Rep. 2019 Apr;39(4):BSR20190477 |
2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine - Nature
Open Data Verified Data
white or off-white crystalline powder, odorless, bitter. Soluble in methanol or dilute hydrochloric acid, soluble in ethanol, slightly soluble in isopropanol, slightly soluble in water. The melting point was 141-143 °c. The solubility in water was 1. 14% at 37 ℃.
Last Update：2024-01-02 23:10:35
2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine - Preparation Method
Open Data Verified Data
4-hydroxymethyl -5-methyl -1H-triazole hydrochloride and 2-aminoethyl mercaptol alcohol hydrochloride, in the presence of hydrogen bromide reaction, and then neutralized with potassium carbonate, the resulting compound is reacted with the corresponding thiourea to give cimetidine.
Last Update：2022-01-01 09:22:49
2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine - Standard
Authoritative Data Verified Data
This product is 1-methyl -2-methyl -3-[2-[[(5-methylimidazol-4-yl) methyl] Thio] ethyl] guanidine. The content of C10H16N6S shall not be less than 99.0% calculated on a dry basis.
Last Update：2024-01-02 23:10:35
2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder; Almost odorless.
- This product is soluble in methanol, soluble in ethanol, slightly soluble in isopropanol, slightly soluble in water; Soluble in dilute hydrochloric acid.
absorption coefficient
take this product, precision weighing, and hydrochloric acid solution (0.9 -1000) dissolved and quantitatively diluted into a solution containing about 8ug per lml, the absorbance was measured at a wavelength of 0401 NM according to ultraviolet-visible spectrophotometry (General rule 751), and the absorption coefficient was 797.
Last Update：2022-01-01 11:44:17
2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine - Use
Open Data Verified Data
histamine H2 receptor antagonist. It can inhibit the gastric acid secretion caused by histamine stimulation, and can inhibit the gastric acid secretion induced by food, pentagastrin, caffeine and insulin, and can also inhibit the basal gastric acid secretion. For gastric and duodenal ulcer, Peptic esophagitis.
Last Update：2022-01-01 09:22:50
2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine - Differential diagnosis
Authoritative Data Verified Data
- take about 50mg of this product, add 10ml of water, and dissolve it at a slight temperature. Add 1 drop of ammonia test solution and 1 drop of copper sulfate test solution to generate blue-gray precipitate; Add excess ammonia test solution to dissolve the precipitate.
- This product is about 50mg, and the gas generated can make the lead acetate test paper black.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 142).
Last Update：2022-01-01 11:44:17
2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine - Safety
Open Data Verified Data
mouse, rat LDso( mg]kg):2600,5000 orally; 150,106 intravenously; 470, 650 intraperitoneally.
Last Update：2022-01-01 09:22:50
2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine - Exam
Authoritative Data Verified Data
clarity and color of acidic solution
take 3.0g of this product, add 1 mol / L hydrochloric acid solution 12ml to dissolve, dilute to 20ml with water, shake, the solution should be clear and colorless; If it is turbid, it shall not be more concentrated than the turbidity standard liquid No. 1 (General rule 0902 method 1); If it is colored, it shall not be deeper than the yellow Standard Colorimetric liquid No. 3 (General rule 0901 method 1). (For injection)
chloride
take l.Og of this product and check it according to law (General rule 0801). Compared with the control solution made of 8ml of standard sodium chloride solution, it should not be more concentrated (0.008%).
Related substances
take this product, add mobile phase to dissolve and dilute to make a solution containing 0.4mg per lml, as a test solution; Take appropriate amount of precision, control Solutions (1) and (2) containing 2UG and 0.2ug per 1 ml were prepared by dilution with mobile phase. Determined by high performance liquid chromatography (General 0512). Silica gel bonded with eighteen alkyl silane was used as the filler; Methanol-water (240:760)(containing phosphoric acid 0.94 and sodium hexanesulfonate g per ml) was used as the mobile phase; The detection wavelength was 220mn. Take about 40mg of this product, put it in a 100ml measuring flask, add lmol/ L hydrochloric acid solution 10ml water bath heating for 2 minutes, let it cool, add lmol/ L sodium hydroxide solution 10ml and dilute it with mobile phase to scale, shake well (to use new system), inject 20ul into liquid chromatograph, record chromatogram, the relative retention time of amide analog is about 2.0, the resolution between the amide analog peak and the cimetidine peak should be greater than 8.0. Take the control solution (2)20 u1 and inject the human Liquid Chromatograph. The signal-to-noise ratio of cimetidine peak should be greater than 10, they were injected into the liquid chromatograph, and the chromatogram was recorded to 3.5 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.4 times (0.2%) of the area of the main peak of the control solution (1), the sum of each impurity peak area shall not be greater than 2 times (1.0%) the area of the main peak of the control solution (1). Test Solution chromatogram is smaller than the control solution (2) the main peak area of 0.5 times the chromatographic peaks are ignored.
loss on drying
take this product, dry to constant weight at 105 ℃, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
precious metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
Last Update：2022-01-01 11:44:18
2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine - Content determination
Authoritative Data Verified Data
take this product about 0.2g, precision weighing, add glacial acetic acid 60ml dissolved, add crystal violet indicator liquid 1 drop, with high gas acid titration solution (0.1 mol/L) titration to the solution is exactly blue, and the result of the titration is corrected with a blank test. Each 1ml of perchloric acid titration solution (0.1 mol/L) corresponds to 25.23mg of C10H16N6S.
Last Update：2022-01-01 11:44:19
2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine - Category
Authoritative Data Verified Data
H2 receptor blockers.
Last Update：2022-01-01 11:44:19
2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:44:19
2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine - Cimetidine tablets
Authoritative Data Verified Data
This product contains cimetidine (C10H16N6S) should be 93.0% to 107.0% of the label.
trait
This product is a white tablet or a light blue or light green tablet with colorant, or a film-coated tablet.
identification
- take an appropriate amount of fine powder of this product (about 0.lg equivalent to cimetidine), heat and burn, and the gas generated can make the lead acetate test paper black.
- take an appropriate amount of fine powder of this product (about 0.lg of cimetidine), add 10ml of methanol, shake to dissolve cimetidine, filter, and use it as a test solution, A solution containing 10 mg of cimetidine per 1 ml was prepared in methanol as a control solution. According to the thin layer chromatography (General 0502) test, absorb the above two solutions each 5 u1, respectively, on the same silica gel G thin layer plate, with chloroform-fermentation (5:1) in order to develop the solvent, expand, dry, and set the iodine vapor in the color, the position and color of the main spot of the test solution should be consistent with the main spot of the reference solution.
examination
- dissolution of this product, according to the dissolution and release determination method (General rule 0931 The first method), hydrochloric acid solution (0.9-1000)900ml as the dissolution medium, the rotation speed is 100 rpm, and the operation is carried out according to law. After 15 minutes, about 10ml of the solution is taken, filtered, and the appropriate amount of the filtrate is taken, A solution containing about 5-10ug per 1 ml was prepared by dilution with the same dissolution medium. The absorbance was measured at a wavelength of 0401 NM according to ultraviolet-visible spectrophotometry (General rule 774), and the elution amount of each tablet was calculated as the absorption coefficient of C10H16N6S was. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 20 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (about 0.15g equivalent to cimetidine), put it in a 200ml measuring flask, add hydrochloric acid solution (0.9-1000) after shaking to dissolve cimetidine, dilute to the scale with the above solvent, shake well, filter, and precisely measure 2ml of continued filtrate, place it in a 200ml measuring flask, dilute to the scale with the above solvent and shake. The absorbance was measured at a wavelength of 0401 NM according to ultraviolet-visible spectrophotometry (General rule 774), and the absorption coefficient of C10H16N6S was calculated.
category
Same as cimetidine.
specification
(1)0.lg (2)0.2g (3)0.4g (4)0.8g
storage
sealed storage.
Last Update：2022-01-01 11:44:20
2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine - Cimetidine capsules
Authoritative Data Verified Data
This product contains cimetidine (C10H16N6S) should be 90.0% to 110.0% of the label.
identification
- take an appropriate amount of the content of this product (about 0.lg equivalent to cimetidine), heat and burn, and the gas generated can make the lead acetate test paper black.
- take an appropriate amount of the contents of this product (approximately equivalent to cimetidine O.lg), add methanol 10ml, shake to dissolve cimetidine, filter, as a test solution; Another cimetidine control sample, made with methanol containing 1 0 mg of cimetidine solution per 1 ml, as a control solution. According to the thin layer chromatography (General 0502) test, absorb 5ul of each of the above two solutions, respectively point on the same silica gel G thin layer plate, with three gas methane-methanol (5:1) as the developing solvent, expand, dry, set iodine vapor in the color, the test solution shows the main spot position and color should be consistent with the reference solution of the main spot.
examination
- dissolution of this product, according to the dissolution and release determination method (General rule 0931 The first method), hydrochloric acid solution (0.9-1000)900ml as the dissolution medium, the rotation speed is 100 revolutions per minute, and the operation is carried out according to law. After 20 minutes, the solution is taken 10 ml and filtered; The appropriate amount of the filtrate is accurately taken and diluted with the above dissolution medium to make a solution containing about 1 ml. The absorbance was measured at a wavelength of 0401 NM according to ultraviolet-visible spectrophotometry (General rule 774), and the dissolution amount of each particle was calculated as the absorption coefficient of C10H16N6S was. At the same time, the empty capsule shell was taken for blank correction, and the limit was 75% of the labeled amount, which should be in accordance with the provisions.
- others should comply with the relevant provisions under the capsule (General 0103).
Content determination
take the contents under the difference of loading, mix evenly, weigh an appropriate amount (about 0.15g equivalent to cimetidine) accurately, put it in a 200ml measuring flask, and add hydrochloric acid solution (0.9-1000). After shaking to dissolve cimetidine, dilute to the scale with the above solvent, shake well, filter, and precisely measure 2ml of continued filtrate, place it in a 200ml measuring flask, dilute to the scale with the above solvent and shake. The absorbance was measured at a wavelength of 218mn according to ultraviolet-visible spectrophotometry (General rule 0401), and the absorption coefficient was calculated as 774.
category
Same as cimetidine.
specification
0.2g
storage
sealed storage.
Last Update：2022-01-01 11:44:21
2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine - Cimetidine and sodium chloride injection
Authoritative Data Verified Data
This product is a sterilized aqueous solution of cimetidine and gasified sodium, containing cimetidine (C10H16N6S) and sodium chloride (NaCl) should be 93.0% to 107.0% of the label amount.
trait
This product is a clear colorless liquid.
identification
- take an appropriate amount of this product (about 50mg of cimetidine), add 2 drops of ammonia test solution and 2 drops of copper sulfate test solution to generate blue-gray precipitate, and add excess ammonia test solution to dissolve the precipitate.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- This product is sodium salt and gasification identification (1) of the reaction (General 0301).
examination
- the pH value should be 5.0 to 7.0 (General 0631).
- appropriate amount of related substances should be taken and diluted with mobile phase to prepare a solution containing about 0.4mg of cimetidine per 1 ml as a sample solution, control Solutions (1) and (2) containing 2UG and 0.2ug per 1 ml were prepared by dilution with mobile phase. If there are impurity peaks in the chromatogram of the test solution, the single impurity peak area shall not be greater than the main peak area (0.5%) of the control solution (1), the sum of each impurity peak area shall not be greater than 3 times (1.5%) of the main peak area of the control solution (1). Test Solution chromatogram is smaller than the control solution (2) the main peak area of 0.5 times the chromatographic peaks are ignored.
- The osmolality shall be 0632 ~ 320mOsmol/kg when the product is taken for inspection according to law (General Rule 260).
- the bacterial endotoxin should be taken and checked according to law (General rule 1143). The Endotoxin content in each lml should be less than 0.50EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
- cimetidine was measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Methanol-water (240:760)(containing phosphoric acid per 0.94 and sodium hexane sulfonate g) as mobile phase; the detection wavelength was 220mn. Take an appropriate amount of this product (about 40mg of cimetidine), put it in a 100ml measuring flask, add 10ml of lmol/L hydrochloric acid solution, heat it in a water bath for 2 minutes, let it cool, add 10ml of lmol/L sodium hydroxide solution and neutralize it, dilute to scale with mobile phase, shake well (ready to use new system), take 20u1 injection human liquid chromatograph, record chromatogram, the relative retention time of amide analog is about 2.0, the resolution between the amide analog peak and the cimetidine peak should be greater than 8.0.
- determination of precision take an appropriate amount of this product, quantitative dilution with water to make each lml containing about 0.1 mg of the solution, as the test solution, the precise amount of 10UL was injected into the liquid chromatograph, and the chromatogram was recorded; Another cimetidine reference substance was taken and determined by the same method. According to the external standard method to calculate the peak area, that is.
- preparation of sodium chloride control stock solution a standard sodium ion solution was accurately weighed, and a solution containing 100ug of sodium ion per 1 ml was prepared with water.
- preparation of sample solution: take 5ml of this product for precision measurement, put it in 50ml measuring flask, dilute it with water to scale, shake well, take 1ml for precision measurement, put it in 50ml measuring flask, dilute to scale with water and shake to obtain.
- determination precision: take 3.5ml, 5.5ml, 7.0ml, 8.5ml and 10.5ml of the reference stock solution, put it in a 100ml measuring flask respectively, and dilute it to the scale with water, shake the above solution and the test solution, according to the flame photometric method (General 0407) determination of sodium ion concentration, calculation, that is obtained.
category
Same as cimetidine.
specification
- 50ml: cimetidine 0.2g with sodium chloride 0.45g
- 100ml: cimetidine 0.2g with sodium chloride 0.9g
- 100ml: cimetidine 0.4g with sodium chloride 0.9g
storage
light shielding, closed storage.
Last Update：2022-01-01 11:44:22
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Product Name: Cimetidine Visit Supplier Webpage Request for quotationCAS: 51481-61-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: cimetidine Request for quotation
CAS: 51481-61-9
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 51481-61-9
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
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Product Name: Cimetidine Visit Supplier Webpage Request for quotationCAS: 51481-61-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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