2-fluoro-4-nitrophenolate

Name	2-fluoro-4-nitrophenol
Synonyms	5-Fluoro-2-nitrophen 2-Fluoro-4-nitrophenol o-fluoro-4-nitrophenol 2-fluoro-4-nitrophenol 2-fluoro-4-nitrophenolate Phenol, 2-fluoro-4-nitro-
CAS	403-19-0
InChI	InChI=1/C6H4FNO3/c7-5-3-4(8(10)11)1-2-6(5)9/h1-3,9H/p-1
InChIKey	ORPHLVJBJOCHBR-UHFFFAOYSA-N

Molecular Formula	C6H4FNO3
Molar Mass	157.1
Density	1.4306 (estimate)
Melting Point	120-122 °C (lit.)
Boling Point	281.2±25.0 °C(Predicted)
Flash Point	123.9°C
Solubility	soluble in Methanol
Vapor Presure	0.00212mmHg at 25°C
Appearance	powder to crystal
Color	White to Light yellow
BRN	1944995
pKa	5.67±0.22(Predicted)
Storage Condition	Inert atmosphere,Room Temperature

Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3
HS Code	29089000
Hazard Class	IRRITANT

EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
application	2-fluoro-4-nitrophenol is an organic synthesis intermediate and a pharmaceutical intermediate, which can be used in laboratory research and development processes and chemical production processes.
preparation	adopts the following steps: a) nitrosation reaction: 2-fluorophenol is generated by nitrosation in the presence of dilute hydrochloric acid with 2-fluorophenol as raw material. The concentration of dilute hydrochloric acid is 15 ~ 20%, preferably 15%; The nitrosation reagent is alkali metal nitrite or nitrite, preferably sodium nitrite; The nitrosation reaction temperature is -5~5 ℃, preferably 0 ℃; B) Oxidation reaction: 2-fluoro-4-nitrophenol is prepared by oxidizing 2-fluoro-4-nitrophenol with dilute nitric acid. The concentration of dilute nitric acid used is 15-55%, preferably 30%. The beneficial effects of the present invention are that the preparation process is simple, only a very small amount of isomers are produced during nitrosation, the yield is as high as 90%, the refining is easy, the purity can reach more than 99.5%, and the production cost is reduced.

Last Update：2024-04-10 22:29:15

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CAS: 403-19-0
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Product Name: 2-Fluoro-4-nitrophenol Request for quotation
CAS: 403-19-0
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987

Wechat: 13605431940
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2-fluoro-4-nitrophenolate

2-fluoro-4-nitrophenolate Request for Quotation