2-fluoro-6-bromophenol
2-Bromo-6-fluorophenol
CAS: 2040-89-3
Molecular Formula: C6H4BrFO
2-fluoro-6-bromophenol - Names and Identifiers
| Name | 2-Bromo-6-fluorophenol |
| Synonyms | QR BF FE 2-fluoro-6-bromophenol 2-Bromo-6-fluorophenol 2-BROMO-6-FLUOROPHENOL phenol, 2-bromo-6-fluoro- Phenol, 2-bromo-6-fluoro- TIANFU-CHEM 2040-89-3 2-Bromo-6-fluorophenol |
| CAS | 2040-89-3 |
| InChI | InChI=1/C6H4BrFO/c7-4-2-1-3-5(8)6(4)9/h1-3,9H |
2-fluoro-6-bromophenol - Physico-chemical Properties
| Molecular Formula | C6H4BrFO |
| Molar Mass | 191 |
| Density | 1.764±0.06 g/cm3(Predicted) |
| Melting Point | 50 °C |
| Boling Point | 173.0±20.0 °C(Predicted) |
| Flash Point | 58.4°C |
| Vapor Presure | 0.97mmHg at 25°C |
| pKa | 7.17±0.10(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| Refractive Index | 1.575 |
2-fluoro-6-bromophenol - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Hazard Class | IRRITANT |
2-fluoro-6-bromophenol - Reference Information
| Application | 2-bromo-6-fluorophenol is an intermediate in organic synthesis and a pharmaceutical intermediate, can be used in laboratory research and development process and biochemical production process. |
| preparation | synthesis of 2-fluoro-6-bromophenol: 1) synthesis of sodium 3-fluoro-4-hydroxybenzenesulfonate (B) (steps a and B, sulfonation):a: 112g(1.0mol) of A are added in a reaction kettle, the temperature was raised to about 120 °c and 80ml(1.5mol) of 98% sulfuric acid was slowly added dropwise with stirring over a period of 30 minutes. After completion of the dropwise addition, the reaction was continued at 120 ° C. For 5 hours. After completion of the reaction, the reaction mixture was cooled to 100 °c or lower. B: 400ml of saturated sodium chloride solution was added to the above reaction mixture, and a large amount of sodium salt was precipitated. After complete cooling, filtration and washing with 10% sodium chloride solution twice, results in a yield of 90% G of product B. 2) synthesis of sodium 3-fluoro-6-bromo-4-hydroxybenzenesulfonate (C) (Step c, halogenation) c: all raw materials and equipment were subjected to anhydrous treatment before reaction, and bromine was washed twice with concentrated sulfuric acid and dehydrated. 250ml three bottles with mechanical stirrer, thermometer and separation funnel and reflux condenser. The flask was charged with 171.2g(0.8mol) of B, g of iron powder and of carbon tetrachloride. With stirring and heating to 55 °c in a water bath, the temperature was controlled at 50-60 °c and 134.4g(0.84mol) of bromine was added dropwise over 4 hours. After the addition, heat preservation and stirring were performed for 2 hours. After cooling and filtering, the filtrate was washed with water, alkaline water and water successively, dried and the solvent was distilled off to obtain 199g of product C, with a yield of 85%. 3) synthesis of 2-fluoro-6-bromophenol (D) (step d, deprotection):d: add 146.5g(0.5mol) in a 250ml reactor C and 70% of sulfuric acid solution. After reaction at 180 ° C. For 5 hours, the reaction mixture was cooled to room temperature, and 80% ml of dichloromethane was added for extraction. The extract was washed, dried and the solvent was distilled off to obtain an oily product d76.4 G, with a yield. |
Last Update：2024-04-10 22:29:15
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View History
2-fluoro-6-bromophenol
(1-Aminoethyl)phosphonous acid
35314-34-2
Benzenamine, 2,6-bis(1-methylethyl)-4-(2-methylphenoxy)-
乙二醇丙烯酸脂
清菌脲
2,5-DICHLOROPHENETHYLAMINE
AMITOL
dibutyl hexanedioate
828926-06-3
(1-Aminoethyl)phosphonous acid
35314-34-2
Benzenamine, 2,6-bis(1-methylethyl)-4-(2-methylphenoxy)-
乙二醇丙烯酸脂
清菌脲
2,5-DICHLOROPHENETHYLAMINE
AMITOL
dibutyl hexanedioate
828926-06-3