2-hydroxy-4,6-dimethylnicotinonitrile

2-hydroxy-4,6-dimethylnicotinonitrile - Names and Identifiers

Name	3-Cyano-4,6-dimethyl-2-hydroxypyridine
Synonyms	AKOS B016302 AKOS B029123 AKOS BBS-00008241 TIMTEC-BB SBB004084 SALOR-INT L133671-1EA 4,6-Dimethyl-2-hydroxynicotinonitrile 2-hydroxy-4,6-dimethylnicotinonitrile 4,6-DIMETHYL-2-HYDROXYNICOTINONITRILE 3-Cyano-4,6-dimethyl-2-hydroxypyridine 2-hydroxy-4,6-dimethylpyridine-3-carbonitrile (3R)-4,6-dimethyl-2-oxo-2,3-dihydropyridine-3-carbonitrile (3S)-4,6-dimethyl-2-oxo-2,3-dihydropyridine-3-carbonitrile 5-Cyano-6-hydroxy-2,4-lutidine~4,6-Dimethyl-2-hydroxypyridine-3-carbonitrile 1,2-Dihydro-4,6-dimethyl-2-oxopyridine-3-carbonitrile, 3-Cyano-4,6-dimethylpyridin-2-one
CAS	769-28-8 70254-47-6
EINECS	212-207-5
InChI	InChI=1/C8H8N2O/c1-5-3-6(2)10-8(11)7(5)4-9/h3,7H,1-2H3/t7-/m1/s1
InChIKey	OCYMJCILWYHKAU-UHFFFAOYSA-N

2-hydroxy-4,6-dimethylnicotinonitrile - Physico-chemical Properties

Molecular Formula	C8H8N2O
Molar Mass	148.16
Density	1.1828 (rough estimate)
Melting Point	285-287 °C (lit.)
Boling Point	268.75°C (rough estimate)
Flash Point	140.3°C
Vapor Presure	0.000685mmHg at 25°C
Appearance	powder to crystal
Color	White to Light yellow to Light orange
BRN	130992
pKa	9.06±0.10(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.6000 (estimate)
MDL	MFCD00006269

2-hydroxy-4,6-dimethylnicotinonitrile - Risk and Safety

Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection
UN IDs	3276
WGK Germany	3
RTECS	QT3046500
HS Code	29333990
Hazard Class	IRRITANT

2-hydroxy-4,6-dimethylnicotinonitrile - Introduction

3-Cyano-4, is an organic compound with the chemical formula C9H9N2O. The following is an introduction to some of its properties, uses, methods and safety information:

Nature:
-Appearance: 3-Cyano-4, yellow to red crystals or granular solids.
-Solubility: The compound is insoluble in water, but soluble in organic solvents such as methanol, ethanol and dimethylformamide.
-Melting point: The melting point range is 110~115 ℃.
-Stability: It is stable, but contact with strong oxidants should be avoided.

Use:
3-Cyano-4, often used as an important intermediate in organic synthesis, has a variety of uses, such:
-in drug development, can be used for the synthesis of anti-tumor drugs, antiviral drugs.
-in pesticide research and development, can be used as synthetic insecticides, fungicides, etc.
-In organic synthesis, it can be used to prepare compounds containing pyridine structure.

Preparation Method:
3-Cyano-4, prepared as follows:
1. by the reaction of methyl acetate and 2-hydroxy -4,6-lutidine, 3-acetic acid methyl ester -4,6-dimethyl -2-hydroxyl pyridine is generated.
2. The product is reacted with trifluoroacetic anhydride to generate 3-Cyano-4.

Safety Information:
3-Cyano-4, which has not been fully toxicological studied and therefore lacks relevant safety data. However, as a chemical substance, the following general safety precautions should be taken:
-Avoid inhaling aerosols, dust or vapors.
-Avoid contact with skin, eyes or clothing. In case of accidental contact, rinse immediately with plenty of water and seek medical advice.
-Follow laboratory safety regulations during operation.
-Avoid contact with oxidants, acids and other substances during storage, and store in a dry and well-ventilated place.

Please note that the above information is for reference only. The specific use of this compound should follow the laboratory's safety procedures and refer to relevant literature and safety data sheets.

Last Update：2024-04-09 20:45:29