2-isopropoxy-6-trifluoroMethyl-3H-pyriMidin-4-one
4(3H)-Pyrimidinone, 2-(1-methylethoxy)-6-(trifluoromethyl)-
CAS: 37836-80-9
Molecular Formula: C8H9F3N2O2
2-isopropoxy-6-trifluoroMethyl-3H-pyriMidin-4-one - Names and Identifiers
2-isopropoxy-6-trifluoroMethyl-3H-pyriMidin-4-one - Physico-chemical Properties
| Molecular Formula | C8H9F3N2O2 |
| Molar Mass | 222.16 |
| Density | 1.40±0.1 g/cm3(Predicted) |
| Boling Point | 191.8±50.0 °C(Predicted) |
| pKa | 6.17±0.50(Predicted) |
2-isopropoxy-6-trifluoroMethyl-3H-pyriMidin-4-one - Introduction
4(3H)-Pyrimidinone, 2-(1-methyllethoxy)-6-(trifluoromethyl)-is an organic compound with the chemical formula C9H10F3NO2, which belongs to pyrimidine derivatives.
Nature:
1. Appearance: colorless to light yellow solid.
2. Melting point: about 49-53°C.
3. Boiling point: about 285°C.
4. density: about 1.331 g/cm ^ 3.
5. Solubility: insoluble in water, soluble in alcohol and ketone organic solvents.
Use:
1. 4(3H)-Pyrimidinone, 2-(1-methyllethoxy)-6-(trifluoromethyl)-is a pesticide active fragment, which is used to synthesize pesticides and fungicides.
2. It can be used as an intermediate for the preparation of other diverse compounds and for organic synthesis reactions.
Preparation Method:
Generally, the preparation of 4(3H)-Pyrimidinone, 2-(1-methyllethoxy)-6-(trifluoromethyl)-involves the following steps:
1. Trifluoromethyl chloride is introduced onto pyrimidine in an appropriate solvent.
2. Pyrimidine and trifluoromethyl chloride are reacted under inert gas, and an appropriate base, such as triethylamine or pyridine, is added.
3. Under the catalysis of alkali, 2-isopropanol is used to introduce isopropoxy groups through esterification.
Safety Information:
1. 4(3H)-Pyrimidinone, 2-(1-methyllethoxy)-6-(trifluoromethyl)-Avoid contact with skin and eyes during operation, and pay attention to avoid inhalation or intake.
2. When using the compound, follow appropriate laboratory practices and safe operating procedures, and wear appropriate personal protective equipment, such as laboratory gloves and protective glasses.
3. Waste should be disposed of in accordance with local regulations to avoid environmental pollution.
Please note that the information provided here is for informational purposes only and relevant data and safety information should be verified prior to use.
Nature:
1. Appearance: colorless to light yellow solid.
2. Melting point: about 49-53°C.
3. Boiling point: about 285°C.
4. density: about 1.331 g/cm ^ 3.
5. Solubility: insoluble in water, soluble in alcohol and ketone organic solvents.
Use:
1. 4(3H)-Pyrimidinone, 2-(1-methyllethoxy)-6-(trifluoromethyl)-is a pesticide active fragment, which is used to synthesize pesticides and fungicides.
2. It can be used as an intermediate for the preparation of other diverse compounds and for organic synthesis reactions.
Preparation Method:
Generally, the preparation of 4(3H)-Pyrimidinone, 2-(1-methyllethoxy)-6-(trifluoromethyl)-involves the following steps:
1. Trifluoromethyl chloride is introduced onto pyrimidine in an appropriate solvent.
2. Pyrimidine and trifluoromethyl chloride are reacted under inert gas, and an appropriate base, such as triethylamine or pyridine, is added.
3. Under the catalysis of alkali, 2-isopropanol is used to introduce isopropoxy groups through esterification.
Safety Information:
1. 4(3H)-Pyrimidinone, 2-(1-methyllethoxy)-6-(trifluoromethyl)-Avoid contact with skin and eyes during operation, and pay attention to avoid inhalation or intake.
2. When using the compound, follow appropriate laboratory practices and safe operating procedures, and wear appropriate personal protective equipment, such as laboratory gloves and protective glasses.
3. Waste should be disposed of in accordance with local regulations to avoid environmental pollution.
Please note that the information provided here is for informational purposes only and relevant data and safety information should be verified prior to use.
Last Update：2024-04-10 22:29:15
