2-methylthiophene-3-thiol
2-methylthiophene-3-thiol
CAS: 2527-76-6
Molecular Formula: C5H6S2
2-methylthiophene-3-thiol - Names and Identifiers
| Name | 2-methylthiophene-3-thiol |
| Synonyms | methyl thiophene thiol 2-Methyl-3-thienylthiol 2-Methyl-3-thiophenethiol 2-methylthiophene-3-thiol 3-Thiophenethiol, 2-methyl- 2-Methyl-3-mercaptothiophene methyl-thiophenethiol,2-methyl-3-thiophenethiol |
| CAS | 2527-76-6 |
| EINECS | 219-770-6 |
| InChI | InChI=1/C5H6S2/c1-4-5(6)2-3-7-4/h2-3,6H,1H3 |
2-methylthiophene-3-thiol - Physico-chemical Properties
| Molecular Formula | C5H6S2 |
| Molar Mass | 130.23 |
| Density | 1.208 |
| Boling Point | 189℃ |
| Flash Point | 68℃ |
| Vapor Presure | 0.789mmHg at 25°C |
| pKa | 6.57±0.48(Predicted) |
| Refractive Index | 1.615 |
2-methylthiophene-3-thiol - Introduction
2-methylthiophene-3-thiol(2-methylthiophene-3-thiol) is an organic compound with the chemical formula C5H6S. The following is a description of its nature, use, preparation and safety information:
Nature:
2-methylthiophene-3-thiol is a yellow to tan liquid with a special thiol (rotten bird egg) taste. It is insoluble in water at room temperature, but soluble in most organic solvents, such as alcohols, ethers and ketones. It has a melting point of -18°C and a boiling point of 188°C.
Use:
2-methylthiophene-3-thiol is often used in organic synthesis as an important intermediate. It can be used to synthesize various compounds with thiophene structure, such as drugs, dyes, photosensitizers and organic semiconductors. In addition, it can also be used as a solvent, desulfurizer and scale inhibitor.
Method:
2-methylthiophene-3-thiol can be prepared by the following methods:
1. Isothiocyanate method: 2-methyl -3-thiophenone is reacted with isothiocyanate to generate 2-methyl -3-thienylthionyl isothiocyanate, which is then hydrolyzed with alcohol or thiol to obtain 2-methylthiophene-3-thiol.
2. Relatively stable metal salt/reducing agent method: 2-methyl -3-thiophenone reacts with sodium peroxide or sodium arsenite to generate the corresponding two hydrides. Reduction with a dihydride reducing agent such as zinc provides 2-methylthiophene-3-thiol.
Safety Information:
2-methylthiophene-3-thiol is irritating and may cause irritation and discomfort in contact with skin and eyes. Use safe practices and wear appropriate protective equipment such as gloves, goggles and protective clothing. Avoid breathing its vapors or dust and ensure that the work area is well ventilated. If accidental exposure or ingestion occurs, seek medical attention immediately.
Nature:
2-methylthiophene-3-thiol is a yellow to tan liquid with a special thiol (rotten bird egg) taste. It is insoluble in water at room temperature, but soluble in most organic solvents, such as alcohols, ethers and ketones. It has a melting point of -18°C and a boiling point of 188°C.
Use:
2-methylthiophene-3-thiol is often used in organic synthesis as an important intermediate. It can be used to synthesize various compounds with thiophene structure, such as drugs, dyes, photosensitizers and organic semiconductors. In addition, it can also be used as a solvent, desulfurizer and scale inhibitor.
Method:
2-methylthiophene-3-thiol can be prepared by the following methods:
1. Isothiocyanate method: 2-methyl -3-thiophenone is reacted with isothiocyanate to generate 2-methyl -3-thienylthionyl isothiocyanate, which is then hydrolyzed with alcohol or thiol to obtain 2-methylthiophene-3-thiol.
2. Relatively stable metal salt/reducing agent method: 2-methyl -3-thiophenone reacts with sodium peroxide or sodium arsenite to generate the corresponding two hydrides. Reduction with a dihydride reducing agent such as zinc provides 2-methylthiophene-3-thiol.
Safety Information:
2-methylthiophene-3-thiol is irritating and may cause irritation and discomfort in contact with skin and eyes. Use safe practices and wear appropriate protective equipment such as gloves, goggles and protective clothing. Avoid breathing its vapors or dust and ensure that the work area is well ventilated. If accidental exposure or ingestion occurs, seek medical attention immediately.
Last Update：2024-04-09 20:52:54
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2-methylthiophene-3-thiol
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(6R,7R)-7-{[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
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