2-oxo-1-phenylhydrazinolate
Cupferron
CAS: 135-20-6
Molecular Formula: C6H9N3O2
2-oxo-1-phenylhydrazinolate - Names and Identifiers
| Name | Cupferron |
| Synonyms | copperone Cupferron CUPEFERRON CUPFERRON,REAGENT,ACS Cupferron for analysis 2-oxo-1-phenylhydrazinolate N-Ammonium oxy-N-nitrosoaniline N-Ammonium oxy-N-nitrosobenzenamine ammonium 2-oxo-1-phenylhydrazinolate N-(Ammonium oxy)-N-nitrosophenylamine Ammonium N-nitroso-N-phenylhydroxylamine N-Nitrosophenylhydroxylamine ammonium salt N-Nitroso-N-phenylhydroxyamine ammonium salt N-Hydroxy-N-nitrosobenzenamine ammonium salt N-Nitroso-N-phenylhydroxylamine ammonium salt |
| CAS | 135-20-6 |
| EINECS | 205-183-2 |
| InChI | InChI=1/C6H6N2O2.H3N/c9-7-8(10)6-4-2-1-3-5-6;/h1-5,10H;1H3/p+1 |
| InChIKey | GDEBSAWXIHEMNF-UHFFFAOYSA-O |
2-oxo-1-phenylhydrazinolate - Physico-chemical Properties
| Molecular Formula | C6H9N3O2 |
| Molar Mass | 155.15 |
| Density | 1.3092 (rough estimate) |
| Melting Point | 150-155 °C (dec.) (lit.) |
| Boling Point | 278.95°C (rough estimate) |
| Flash Point | 101.3°C |
| Solubility | well soluble in water and ethanol. |
| Vapor Presure | 0.0169mmHg at 25°C |
| Appearance | White crystal |
| Color | Needles from water |
| Merck | 14,2622 |
| BRN | 3919107 |
| Storage Condition | 2-8°C |
| Stability | Stable, but may be moisture sensitive. Incompatible with strong oxidizing agents, strong bases, strong acids. |
| Sensitive | Sensitive to light and heat |
| Refractive Index | 1.6500 (estimate) |
| MDL | MFCD00078422 |
| Physical and Chemical Properties | White or milk-colored scaly crystals. Melting point 163-164 ℃, soluble in water and alcohol. |
| Use | For aluminum, bismuth, copper, iron, gallium, Mercury, manganese, niobium, tin, tantalum, thorium, titanium, vanadium, zirconium and other elements of quantitative analysis |
2-oxo-1-phenylhydrazinolate - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R40 - Limited evidence of a carcinogenic effect R45 - May cause cancer R43 - May cause sensitization by skin contact R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S53 - Avoid exposure - obtain special instructions before use. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | NC4725000 |
| TSCA | Yes |
| HS Code | 29299090 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | TDLo orl-rat: 123 g/kg/78W-C:CAR NCITR* NCI-CGTR-100,78 |
2-oxo-1-phenylhydrazinolate - Nature
Open Data Verified Data
White or milky white, lustrous, scaly crystals. Long-standing color darkening. mp163 ~ 164. Soluble in water, ethanol. White or brownish scaly crystals.
Last Update：2024-01-02 23:10:35
2-oxo-1-phenylhydrazinolate - Preparation Method
Open Data Verified Data
The phenylethylene ether solution was cooled, excess ammonia was introduced, and n-butyl nitrite was added dropwise. The cupric-ferric reagent precipitate was filtered off, washed with ether, and dried.
Last Update：2022-01-01 09:26:03
2-oxo-1-phenylhydrazinolate - Introduction
It is easily soluble in water and alcohol, and the color becomes darker for a long time. Generally, a small amount of ammonium carbonate wrapped in paper (or cloth) is placed in the bottle as a stabilizer.
Last Update：2022-10-16 17:13:34
2-oxo-1-phenylhydrazinolate - Use
Open Data Verified Data
for the separation of copper and iron from other metal ions, precipitation determination of iron from strong acid solutions I Colorimetric Determination of aluminum. It is also used for the determination of bismuth, gallium, Mercury, manganese, niobium, tin, tantalum, thorium, zirconium and other elements.
Last Update：2022-01-01 09:26:04
2-oxo-1-phenylhydrazinolate - Safety
Open Data Verified Data
rat oral MLD: 250mg/kg. There is a potential for cancer. In general, a small amount of ammonium carbonate is placed in the packaging bottle as a stabilizer.
Last Update：2022-01-01 09:26:04
2-oxo-1-phenylhydrazinolate - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| (IARC) carcinogen classification | 2B (Vol. 127) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Analytical reagent | Copper-iron reagent is an important analytical reagent, which is the ammonium salt of N-nitrosolamine, commonly known as copper iron Ling. Usually it is white or light yellow bright scaly crystals with sweet taste, and the color becomes dark due to slow decomposition for a long time, but it can actually be used in analysis. It is easily soluble in water, benzene, alcohol, and ether. The reagent is decomposed by heat to produce nitrobenzene. It is unstable in light and air and needs to be stored in a brown grinding reagent bottle. Usually a small amount of ammonium carbonate wrapped in paper or cloth is placed in the bottle as a preservative and placed in a sealed and dark place. It can be used as a precipitant and solvent extractant for copper, iron, tin, titanium, vanadium, chromium and other elements, and as a masking agent for the determination of rare earths. The nitrobenzene is reduced with zinc powder in an aqueous solution of ammonium chloride to obtain phenylhydroxylamine, and then the latter is dissolved in ether, excess ammonia is introduced, and n-butyl nitrite is added to obtain The copper-iron reagent can form a stable five-membered ring chelate with a variety of metal ions. Therefore, it is a commonly used organic precipitant. It can quantitatively determine Fe3 ions in strong acid solutions, and can also determine Cu2 ,Sn4 ,Ti4 ,Ga3 ,Hf4 plasma and vanadate (VO-3,VO3-3). When Fe3 ,Cu2 ions are mixed with other metal ions, this reagent can be used to separate them. It is also a chelating extractant for Al3 ,Au3 ,Be2 ,Co2 ,La3 ,Pu4 plasma and a masking agent for the determination of rare earth metal ions. |
| purification method | 30g of powdered crude product is added to 120ml60 ℃ water to dissolve it all, 2g of powdered activated carbon is added, stirred for 10-15min, filtered with burned Brinell funnel, cooled the filtrate to 10-15 ℃, then cooled to 0 ℃ and left overnight. The precipitated crystals were filtered out with a glass sand funnel, washed with 10ml of ethanol, washed with 10ml of ether, and dried in air. Copper and iron reagents can also be refined by recrystallization with ethanol. |
| use | chemical analysis reagent to determine aluminum, copper, iron, titanium, zirconium and other metals. used for quantitative analysis of aluminum, bismuth, copper, iron, gallium, mercury, manganese, niobium, tin, tantalum, thorium, titanium, vanadium, zirconium and other elements polymerization inhibitor, due to its unique Cupferron The polymerization resistance characteristics and the small amount, can be used as an alternative to the currently widely used phenol polymerization inhibitor BHT. Colorimetric determination of aluminum, bismuth, copper, iron mercury, zinc, manganese, niobium, gallium, tantalum, thorium, titanium, vanadium, tin and other elements. Quantitative determination of iron in strong acid solution, quantitative analysis of vanadate, separation of copper and iron when together with other metals, measurement of rare earth as a masking agent. Used to separate copper and iron from other metal ions and precipitate and determine iron from strong acid solution; used for quantitative determination of vanadate to form dark red precipitate and quantitative determination of titanium to form yellow precipitate; used for colorimetric determination of aluminum |
| production method | the phenylhydroxylamine ether solution is cooled in ice solution, ammonia is introduced to an excess amount, n-butyl nitrite is added dropwise under the condition of stirring and continuous ammonia application, the addition is completed in about 1 hour, and then stirred for 15min. Filter out the copper iron precipitate, wash with ether, and dry to obtain the finished product. The product should be stored in a brown glass bottle with a small amount of ammonium carbonate wrapped in paper (or cloth) as a stabilizer. |
| category | pesticide |
| toxicity classification | highly toxic |
| acute toxicity | oral-rat LD 50: 199 mg/kg; Intravenous-mouse LD50:180 mg/kg |
| stimulation data | eyes-rabbit 20 mg/24 hours moderate |
| explosive hazard characteristics | solution with thorium salt, zirconium salt or titanium salt detonate at room temperature |
| flammability hazard characteristics | toxic nitrogen oxides and ammonia smoke generated at high temperatures |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:06
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