2-p-tolylpropan-2-amine

2-p-tolylpropan-2-amine - Names and Identifiers

Name	2-p-tolylpropan-2-amine
Synonyms	2-p-tolylpropan-2-amine 2-(4-methoxyphenyl)propan-2-amine 1-(4-methoxyphenyl)-1-methylethylamine 1-(4-Methoxyphenyl)-1-methylethylamine BenzeneMethanaMine, 4-Methoxy-a,a-diMethyl- Benzenemethanamine, 4-methoxy-α,α-dimethyl-
CAS	30568-44-6
InChI	InChI=1/C10H15NO/c1-10(2,11)8-4-6-9(12-3)7-5-8/h4-7H,11H2,1-3H3

2-p-tolylpropan-2-amine - Physico-chemical Properties

Molecular Formula	C10H15NO
Molar Mass	165.23
Density	0.987±0.06 g/cm3(Predicted)
Boling Point	253.7±23.0 °C(Predicted)
Flash Point	103.8°C
Vapor Presure	0.018mmHg at 25°C
pKa	9.62±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.512

2-p-tolylpropan-2-amine - Risk and Safety

Hazard Class

IRRITANT

2-p-tolylpropan-2-amine - Introduction

2-p-tolylpropan-2-amine, also known as 2-p-tolylpropanamine, is an organic compound.

Nature:
The chemical formula of this compound is C11H17NO, and its molecular weight is 179.26g/mol. It has a colorless to pale yellow solid, is soluble in organic solvents such as dimethyl sulfoxide and acetonitrile at normal temperature, and is insoluble in water. Its melting point is about 38-41 degrees Celsius.

Use:
2-p-tolylpropan-2-amine has important application value in the pharmaceutical field. It is used as an intermediate in the synthesis of drugs and biologically active molecules. In addition, it can also be used as a reagent in organic synthesis and participate in a variety of organic reactions.

Method:
The preparation method of 2-p-tolylpropan-2-amine is generally achieved by N-methylation reaction. The specific steps are as follows:
1. Acetophenone is reacted with P-methylaniline to obtain p-methylacetophenone.
2. P-Methylacetophenone and methyl iodide are reacted under alkaline conditions to obtain 1-(4-methoxyphenyl)-1-methylethanone.
3. Finally, 1-(4-methoxyphenyl)-1-methylethanone is condensed with methyl carbamate in an alkaline solution to produce 2-p-tolylpropan-2-amine.

Safety Information:
2-p-tolylpropan-2-amine is not currently classified as a toxic substance, but should be used with appropriate safety precautions, such as wearing gloves, goggles, and providing adequate ventilation. In addition, it should be kept away from fire and oxidizing agents and stored in a dry, sealed container. Avoid dust or eye splashes during handling and storage. If accidental contact or misuse occurs, seek medical attention immediately.

Last Update：2024-04-09 21:00:56