2-piperazin-1-ylbenzonitrile
Cyanophenylpiperazine
CAS: 111373-03-6
Molecular Formula: C11H13N3
2-piperazin-1-ylbenzonitrile - Names and Identifiers
| Name | Cyanophenylpiperazine |
| Synonyms | RARECHEM AH CK 0076 Cyanophenylpiperazine 1-(2-CYANOPHENYL)PIPERAZINE 1-(2-CYANPHENYL)-PIPERAZINE 1-(2-Cyanophenyl)piperazine 2-(1-Piperazino)benzonitrile 2-piperazin-1-ylbenzonitrile Benzonitrile, 2-(1-piperazinyl)- (9CI) |
| CAS | 111373-03-6 |
| InChI | InChI=1/C11H13N3/c12-9-10-3-1-2-4-11(10)14-7-5-13-6-8-14/h1-4,13H,5-8H2 |
2-piperazin-1-ylbenzonitrile - Physico-chemical Properties
| Molecular Formula | C11H13N3 |
| Molar Mass | 187.24 |
| Density | 1.115 g/mL |
| Melting Point | 113-115 |
| Boling Point | 314-315 °C (lit.) |
| Flash Point | 118°F |
| Vapor Presure | 1.19E-05mmHg at 25°C |
| Appearance | clear liquid |
| Specific Gravity | 1.115 |
| Color | Colorless to Light orange to Yellow |
| BRN | 785973 |
| pKa | 8.77±0.10(Predicted) |
| Sensitive | Moisture Sensitive |
| Refractive Index | n20/D 1.5890(lit.) |
2-piperazin-1-ylbenzonitrile - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R10 - Flammable R36 - Irritating to the eyes |
| Safety Description | S16 - Keep away from sources of ignition. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| Hazard Class | 8 |
| Packing Group | II |
2-piperazin-1-ylbenzonitrile - Introduction
Cyanophenylpiperazine is an organic compound with the chemical formula C13H13N5. It has the following properties:
1. appearance: cyanophenyl piperazine is a solid, common white crystalline powder or crystal.
2. Solubility: cyanophenyl piperazine is soluble in many commonly used organic solvents, such as ethanol, ether and dimethyl sulfide.
3. chemical reaction: the compound can generate cyanate hydrochloride of cyanophenylpiperazine by cyanation reaction.
Cyanophenyl piperazine has a wide range of applications in the field of medicine. It is used as a specific serotonin reuptake inhibitor of the central nervous system and can treat depression and anxiety by regulating serotonin levels in the brain. In addition, it is used as a shock-resistant drug and as an antihypertensive drug.
The method for preparing cyanophenyl piperazine includes reacting aniline with sodium cyanide to generate phenyl amino carbon mica salt, and then reacting with 2-chloro-4-cyanopiperazine to obtain cyanophenyl piperazine.
Regarding safety information, cyanophenylpiperazine is a chemical and should be followed in accordance with relevant safety procedures. It can be irritating and should avoid contact with the skin, eyes, and respiratory tract. When using, wear protective glasses and gloves, and ensure that the operation is carried out in a well-ventilated environment. In case of inadvertent ingestion or contact, seek medical help immediately and provide a safety data sheet for the compound.
1. appearance: cyanophenyl piperazine is a solid, common white crystalline powder or crystal.
2. Solubility: cyanophenyl piperazine is soluble in many commonly used organic solvents, such as ethanol, ether and dimethyl sulfide.
3. chemical reaction: the compound can generate cyanate hydrochloride of cyanophenylpiperazine by cyanation reaction.
Cyanophenyl piperazine has a wide range of applications in the field of medicine. It is used as a specific serotonin reuptake inhibitor of the central nervous system and can treat depression and anxiety by regulating serotonin levels in the brain. In addition, it is used as a shock-resistant drug and as an antihypertensive drug.
The method for preparing cyanophenyl piperazine includes reacting aniline with sodium cyanide to generate phenyl amino carbon mica salt, and then reacting with 2-chloro-4-cyanopiperazine to obtain cyanophenyl piperazine.
Regarding safety information, cyanophenylpiperazine is a chemical and should be followed in accordance with relevant safety procedures. It can be irritating and should avoid contact with the skin, eyes, and respiratory tract. When using, wear protective glasses and gloves, and ensure that the operation is carried out in a well-ventilated environment. In case of inadvertent ingestion or contact, seek medical help immediately and provide a safety data sheet for the compound.
Last Update：2024-04-09 20:02:46
