2-piperazone
Piperazin-2-one
CAS: 5625-67-2
Molecular Formula: C4H8N2O
2-piperazone - Names and Identifiers
| Name | Piperazin-2-one |
| Synonyms | 2-piperazone PIPERAZINONE 2-PIPERAZINONE PIPERAZIN-2-ONE Piperazin-2-one 2-OXOPIPERZAINE 2-OXOPIPERAZINE 2-Oxopiperazine PIPERAZINE-2-ONE Piperazine-2-one AKOS BBS-00007028 TIMTEC-BB SBB000034 3-oxopiperazin-1-ium |
| CAS | 5625-67-2 |
| InChI | InChI=1/C4H8N2O/c7-4-3-5-1-2-6-4/h5H,1-3H2,(H,6,7)/p+1 |
| InChIKey | IWELDVXSEVIIGI-UHFFFAOYSA-N |
2-piperazone - Physico-chemical Properties
| Molecular Formula | C4H8N2O |
| Molar Mass | 100.12 |
| Density | 1.053±0.06 g/cm3(Predicted) |
| Melting Point | 136-140 °C (lit.) |
| Boling Point | 164°C/5mmHg(lit.) |
| Flash Point | 166.3°C |
| Solubility | Chloroform |
| Vapor Presure | 0.000738mmHg at 25°C |
| Appearance | Solid |
| Color | White to tan |
| pKa | 15.47±0.20(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Stability | Stable, but may be light and moisture sensitive. Incompatible with oxidizing agents. |
| Sensitive | Hygroscopic |
| MDL | MFCD01318687 |
2-piperazone - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R43 - May cause sensitization by skin contact |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | 1759 |
| WGK Germany | 3 |
| HS Code | 29349990 |
| Hazard Class | 8 |
| Packing Group | III |
2-piperazone - Reference Information
| Application | 2-piperazinone is an important intermediate in organic synthesis and pharmaceutical intermediates, used in the synthesis of piperazine, norfloxacin, pipemidic acid, quinone and intermediates for the production of anthelmintic, anti-tuberculosis, antibacterial, treatment of diabetes and other drugs. In addition, it is also used to synthesize textile dyeing and finishing auxiliaries, rubber vulcanization accelerators, antioxidants, preservatives, stabilizers, synthetic resins, synthetic fibers, synthetic leather and other raw materials, and is widely used. |
| preparation | add 7.9g of chloroethylamine, 12.2g of ethyl chloroacetate and 400 g of toluene to a reaction kettle, after reaction for 24h, 7.7g ammonium acetate and 2.2 g sodium carbonate were added, and the reaction temperature was controlled at 80 ℃, the mixture was left to cool to room temperature, filtered and dried to obtain a crude product. The product was recrystallized from acetone-water and decolorized with activated carbon to obtain pale white crystals of 5.5 g in a yield of 55%. |
Last Update：2024-04-09 20:52:54
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