2-sulfanilamidothiazole
Sulfathiazloe
CAS: 72-14-0
Molecular Formula: C9H9N3O2S2
2-sulfanilamidothiazole - Names and Identifiers
| Name | Sulfathiazloe |
| Synonyms | ST thiazamide Sulfavitina Sulfathiazloe Sulfathiazole sulfathiazone Sulfathiazole(form3) Sulfathiazole(form1) Sulfanilamidothiazole 2-sulfanilamidothiazole 2-(p-aminobenzenesulfonamido)thiazole 2-(4-AMINOBENZENESULFONAMIDO)THIAZOLE 2-(P-AMINOBENZENESULFONAMIDO)THIAZOLE 4-amino-n-2-thiazolyl-benzenesulfonamide Sulfanilamide, N1-4-thiazolin-2-ylidene- 4-amino-N-(1,3-thiazol-2-yl)benzenesulfonamide |
| CAS | 72-14-0 |
| EINECS | 200-771-5 |
| InChI | InChI=1/C9H9N3O2S2/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9/h1-6H,10H2,(H,11,12) |
| InChIKey | JNMRHUJNCSQMMB-UHFFFAOYSA-N |
2-sulfanilamidothiazole - Physico-chemical Properties
| Molecular Formula | C9H9N3O2S2 |
| Molar Mass | 255.32 |
| Density | 1.4629 (rough estimate) |
| Melting Point | 200-202 °C (lit.) |
| Boling Point | 479.5±47.0 °C(Predicted) |
| Flash Point | 243.8°C |
| Water Solubility | Insoluble (<0.1 g/100 mL at 21 ºC) |
| Solubility | Insoluble in water. Soluble in acetone, dilute hydrochloric acid, ammonia and alkali solution. |
| Vapor Presure | 2.35E-09mmHg at 25°C |
| Appearance | White to pale yellow crystalline powder |
| Color | White |
| Merck | 14,8943 |
| BRN | 226178 |
| pKa | 7.2(at 25℃) |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.6560 (estimate) |
| MDL | MFCD00005319 |
| Physical and Chemical Properties | Melting point 202.5°C water-soluble Insoluble (<0.1g/100 mL at 21 ° |
| Use | Sulfonamides for infections with Pneumonia cocci, meningococci, Neisseria gonorrhoeae, and hemolytic Streptococci |
| In vitro study | In two batch reactors containing different waste water matrices, Sulfathiazole (20 μg/L) began to degrade in one of the reactors on days 31 to 38. In the nitrification process (S3),Sulfathiazole degrades at a substantially higher rate than sulfamethoxazole or sulfamethazine. The percentage of recovery of Sulfathiazole from Tracer fertilizer silt samples at pH 9 was 64%. Sulfathiazole has an acidity constant with a pKa of 7.1 and a retention time (tR) of 7.8. The S/N value of Sulfathiazole was higher than that of 100 at 1 mg/kg level. The adsorption of Sulfathiazole on inorganic adsorbents exhibited a significant pH dependence, consistent with the sorbate morphology and adsorbent charge properties. Sulfathiazole cations are the most important for adsorption to clay minerals, followed by neutral species. Sulfathiazole has at least five crystalline or polymorphic forms: I,II,III,IV, and V. Although both amino and imino forms are possible for the sulfathiazole molecule, Sulfathiazole exists only in the solid imino form. In the presence of ultraviolet B(UV-B), Sulfathiazole (94.9 mg/L) significantly increased the generation of reactive oxygen species (ROS) and lipid peroxidation. Exposure to Sulfathiazole and UV-B light significantly upregulated α-esterase, hemoglobin, and vitellogenin mRNA and significantly affected Daphnia survival. |
2-sulfanilamidothiazole - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | 3249 |
| WGK Germany | 2 |
| RTECS | WP2360000 |
| TSCA | Yes |
| HS Code | 29350090 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
2-sulfanilamidothiazole - Reference
| Reference Show more | 1. Wang Xuefeng, Wei Qingguang, fan Jiangping, et al. Sample pretreatment and detection conditions optimization of three sulfonamides and malachite green in aquatic products [J]. Journal of Food Safety and quality testing, 2018, 9(21):177-183. 2. Kollinger, Kefei, niudejun, et al. Screening of sulfonamide sensitive strains by UV mutagenesis and its application in the detection of milk sulfonamide antibiotics [J]. Modern food science and technology, 2019, 35(5):296-303. 3. Yanmei Han, Zheng Ping Jiang, Zhu Chen, Yan Gu, Yanfang Liu, Xiang Zhang, Xuetao Cao, Pathogen-expanded CD11b invariant ncelt feedback, Journal of Autoimmunity, Volume 58, 2015, Pages 21-35, ISSN 4. [IF=4.759] Ji-Cheng Sun et al."Metal-organic framework modified carbon cloth for electric field enhanced thin film microextraction of sulfonamides in animal-derived food."JOURNAL OF CHROMATOGRAPHY A. 2022 May;:463120 5. [IF=5.833] Hu Wenyao et al."Flexible membrane composite based on sepiolite/chitosan/(silver nanoparticles) for enrichment and surface-enhanced Raman scattering determination of sulfamethoxazole in animal-derived food."MICROCHIMICA ACTA. 2022 May;189(5):1-12 6. [IF=3.365] Guo-Ying Chen et al."Nanozyme based on ZIF-8 for the colorimetric detection of sulfonamides in cow milk."ANALYTICAL BIOCHEMISTRY. 2022 Sep;652:114748 |
2-sulfanilamidothiazole - Nature
Open Data Verified Data
white crystals or crystalline powders. Stable in air, light discoloration. The melting point was 200-204 °c. Insoluble in water, soluble in acetone, dilute hydrochloric acid, ammonia and alkali solution.
Last Update：2024-01-02 23:10:35
2-sulfanilamidothiazole - Preparation Method
Open Data Verified Data
can be prepared by condensation of 2 amino thiazole and chloro p-nitrophenyl sulfonyl, and then by reduction.
Last Update：2022-01-01 10:57:39
2-sulfanilamidothiazole - Introduction
Stable in the air. In case of light, it gradually changes color. Insoluble in water. Soluble in acetone, dilute hydrochloric acid, ammonia and alkali solution.
Last Update：2022-10-16 17:28:09
2-sulfanilamidothiazole - Use
Open Data Verified Data
is a sulfonamides drug used for infections with Pneumonia cocci, meningococci, Neisseria gonorrhoeae, and hemolytic streptococci. To be used for the treatment of hemolytic Streptococcus, meningococcus, Pneumonia cocci and other infectious diseases.
Last Update：2022-01-01 10:57:38
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View History
2-sulfanilamidothiazole
7440-39-3
5059-30-3
司本80
3-hydroxymethyl-5-methylisoxazole
7-Fluoro-6-nitro-4-hydroxy-quinazoline
N-[2-(HYDROXYMETHYL)-2,3-DIHYDRO-1H-BENZO[F]CHROMEN-1-YL]-N,N'-DIMETHYLTHIOUREA
6-溴-2-己酮
3 - thiophene forMic acid
7440-39-3
5059-30-3
司本80
3-hydroxymethyl-5-methylisoxazole
7-Fluoro-6-nitro-4-hydroxy-quinazoline
N-[2-(HYDROXYMETHYL)-2,3-DIHYDRO-1H-BENZO[F]CHROMEN-1-YL]-N,N'-DIMETHYLTHIOUREA
6-溴-2-己酮
3 - thiophene forMic acid