2-氟-6-羟基苯甲酸甲酯
Methyl 6-fluorosalicylate
CAS: 72373-81-0
Molecular Formula: C8H7FO3
2-氟-6-羟基苯甲酸甲酯 - Names and Identifiers
2-氟-6-羟基苯甲酸甲酯 - Physico-chemical Properties
| Molecular Formula | C8H7FO3 |
| Molar Mass | 170.14 |
| Melting Point | 71°C |
| Boling Point | 65-70°C 1,7mm |
| Storage Condition | Inert atmosphere,Room Temperature |
| Sensitive | Irritant |
| MDL | MFCD00153207 |
2-氟-6-羟基苯甲酸甲酯 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Hazard Class | IRRITANT |
2-氟-6-羟基苯甲酸甲酯 - Reference Information
| introduction | methyl 2-fluoro-6-hydroxybenzoate is a pharmaceutical intermediate, which can be made of gallic acid as raw material, treated with methanol esterification and dimethyl sulfate etherification to methyl benzoate substituted by trimethyl ether, and then interact with the complex reagent ZnCl2/CH3CH2COOH to selectively remove methyl ether, methyl 2-fluoro-6-hydroxybenzoate was obtained in higher yield. |
| preparation | under nitrogen protection, gallic acid (10g,0.059mL) is dissolved in 50mL of methanol, concentrated sulfuric acid in catalytic amount is dropped under stirring, reflux for 8 h, sodium hydroxide solution (80 mL,33%) and dimethyl sulfate (60g) are alternately dropped into the reactor. After dropping, sodium hydroxide solution is used to adjust to strong alkalinity. The temperature is raised to 80 ℃ to continue the reaction for 8 hours. After the reaction is completed, chloroform is used for extraction (40 mL × 3), anhydrous sodium sulfate is dried, thin layer detection is a single point, solvent is evaporated, insoluble impurities are filtered out in a short column to obtain white solid methyl 2-fluoro-6-hydroxybenzoate with a yield of 95%. |
Last Update：2024-04-09 20:52:54
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Spot supply
Product Name: Methyl 2-fluoro-6-hydroxybenzoate Visit Supplier Webpage Request for quotationCAS: 72373-81-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Methyl 2-fluoro-6-hydroxybenzoate Visit Supplier Webpage Request for quotationCAS: 72373-81-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
View History
2-氟-6-羟基苯甲酸甲酯
FMOC-NH(CH2)6NH2 HCL
2,4,6-Trimethyl-6-[methylthiomethyl]-2,4-cyclohexadien-1-one
1-二乙氧基乙烯
2',5'-二乙氧基苯酰替苯胺
LITHIUM TRIMETHYLSILANOLATE, 1.0M SOLUTI ON IN DICHLOROMETHANE
聚二甲基硅氧烷乙烯基封端
Pazopanib Impurity 31
葡萄糖-6-磷酸去氢酶
Phosphoric acid tris(4-isopropylphenyl) ester
FMOC-NH(CH2)6NH2 HCL
2,4,6-Trimethyl-6-[methylthiomethyl]-2,4-cyclohexadien-1-one
1-二乙氧基乙烯
2',5'-二乙氧基苯酰替苯胺
LITHIUM TRIMETHYLSILANOLATE, 1.0M SOLUTI ON IN DICHLOROMETHANE
聚二甲基硅氧烷乙烯基封端
Pazopanib Impurity 31
葡萄糖-6-磷酸去氢酶
Phosphoric acid tris(4-isopropylphenyl) ester