2-氨基-5-(4-氯苯基)-1,3,4-噁二唑
2-氨基-5-(4-氯苯基)-1,3,4-噁二唑
CAS: 33621-61-3
Molecular Formula: C8H6ClN3O
2-氨基-5-(4-氯苯基)-1,3,4-噁二唑 - Names and Identifiers
2-氨基-5-(4-氯苯基)-1,3,4-噁二唑 - Physico-chemical Properties
| Molecular Formula | C8H6ClN3O |
| Molar Mass | 195.61 |
| Density | 1.415±0.06 g/cm3(Predicted) |
| Melting Point | 245°C (dec.) |
| Boling Point | 358.3±44.0 °C(Predicted) |
| pKa | -1.42±0.26(Predicted) |
| Storage Condition | Room Temprature |
2-氨基-5-(4-氯苯基)-1,3,4-噁二唑 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
2-氨基-5-(4-氯苯基)-1,3,4-噁二唑 - Introduction
2-amino-5-(4-chlorophenyl)-1,3,4-oxadiazole (2-amino-5-(4-chlorophenyl)-1,3,4-oxadiazole) is an organic compound with the chemical formula C8H6ClN3O. The following is a description of the properties, uses, preparation and safety information of this compound:
Nature:
-Appearance: 2-Amino -5-(4-chlorophenyl)-1,3, 4-oxadiazole is a white to light yellow crystalline solid.
-Melting point: approximately 184-187°C.
-Solubility: It is more soluble in common organic solvents, such as ethanol and dichloromethane.
Use:
-As a pharmaceutical intermediate: 2-amino -5-(4-chlorophenyl)-1,3, 4-oxadiazole is an important intermediate that can be used to synthesize various drugs and biologically active compounds.
-Pesticide: This compound is also used as an intermediate for the synthesis of pesticides.
Preparation Method:
2-amino -5-(4-chlorophenyl)-1,3, 4-oxadiazole can be prepared by the following synthetic route:
1. First, the ortho-nitrobenzene and chloroacetonitrile react to generate 2-amino -5-cyano -4-chlorobenzene.
2. Then, 2-amino -5-cyano-4-chlorobenzene is reacted with carbamate to generate 2-amino -5-(4-chlorophenyl)-1,3, 4-oxadiazole.
Safety Information:
Specific safety information for 2-amino -5-(4-chlorophenyl)-1,3, 4-oxadiazole may vary by country and region. In general, the following basic safety measures should be followed when using chemicals:
-Avoid inhalation or contact with skin. In case of inadvertent contact, flush the affected area immediately with plenty of water and seek medical help.
-Avoid ingestion. If accidentally swallowed, seek medical attention immediately.
-Avoid contact with oxidants and combustibles during storage, and keep a well-ventilated place.
-Wear appropriate personal protective equipment such as laboratory gloves and safety glasses when used.
Please note that this is only a general introduction to 2-amino -5-(4-chlorophenyl)-1,3, 4-oxadiazole, and specific uses and preparation methods may require more detailed research and evaluation in a synthesis laboratory or industrial setting. At the same time, the use and handling of chemicals should strictly follow the relevant regulations and safety operation guidelines.
Nature:
-Appearance: 2-Amino -5-(4-chlorophenyl)-1,3, 4-oxadiazole is a white to light yellow crystalline solid.
-Melting point: approximately 184-187°C.
-Solubility: It is more soluble in common organic solvents, such as ethanol and dichloromethane.
Use:
-As a pharmaceutical intermediate: 2-amino -5-(4-chlorophenyl)-1,3, 4-oxadiazole is an important intermediate that can be used to synthesize various drugs and biologically active compounds.
-Pesticide: This compound is also used as an intermediate for the synthesis of pesticides.
Preparation Method:
2-amino -5-(4-chlorophenyl)-1,3, 4-oxadiazole can be prepared by the following synthetic route:
1. First, the ortho-nitrobenzene and chloroacetonitrile react to generate 2-amino -5-cyano -4-chlorobenzene.
2. Then, 2-amino -5-cyano-4-chlorobenzene is reacted with carbamate to generate 2-amino -5-(4-chlorophenyl)-1,3, 4-oxadiazole.
Safety Information:
Specific safety information for 2-amino -5-(4-chlorophenyl)-1,3, 4-oxadiazole may vary by country and region. In general, the following basic safety measures should be followed when using chemicals:
-Avoid inhalation or contact with skin. In case of inadvertent contact, flush the affected area immediately with plenty of water and seek medical help.
-Avoid ingestion. If accidentally swallowed, seek medical attention immediately.
-Avoid contact with oxidants and combustibles during storage, and keep a well-ventilated place.
-Wear appropriate personal protective equipment such as laboratory gloves and safety glasses when used.
Please note that this is only a general introduction to 2-amino -5-(4-chlorophenyl)-1,3, 4-oxadiazole, and specific uses and preparation methods may require more detailed research and evaluation in a synthesis laboratory or industrial setting. At the same time, the use and handling of chemicals should strictly follow the relevant regulations and safety operation guidelines.
Last Update：2024-04-09 21:11:58
