2-氨基-5-硝基二苯酮
2-Amino-5-nitrobenzophenone
CAS: 1775-95-7
Molecular Formula: C13H10N2O3
2-氨基-5-硝基二苯酮 - Names and Identifiers
| Name | 2-Amino-5-nitrobenzophenone |
| Synonyms | BRN 0748830 2-Benzoyl-4-nitroaniline 2-Amino-5-nitrodiphenylone 2-Amino-5-nitrobenzophenone 5-Nitro-2-aminobenzophenone Benzophenone, 2-amino-5-nitro- 2-Amino-5-nitrodiphenylmethone (2-Amino-5-nitrophenyl)phenylmethanone (2-amino-5-nitrophenyl)phenyl-methanon Methanone,(2-amino-5-nitrophenyl)phenyl- Methanone, (2-amino-5-nitrophenyl)phenyl- 4-14-00-00246 (Beilstein Handbook Reference) |
| CAS | 1775-95-7 |
| EINECS | 217-207-9 |
| InChI | InChI=1/C13H10N2O3/c14-12-7-6-10(15(17)18)8-11(12)13(16)9-4-2-1-3-5-9/h1-8H,14H2 |
2-氨基-5-硝基二苯酮 - Physico-chemical Properties
| Molecular Formula | C13H10N2O3 |
| Molar Mass | 242.23 |
| Density | 1.2480 (rough estimate) |
| Melting Point | 166-168 °C (lit.) |
| Boling Point | 385.05°C (rough estimate) |
| Flash Point | 242.9°C |
| Water Solubility | 3 mg/L (20 C) |
| Solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated) |
| Vapor Presure | 2.65E-09mmHg at 25°C |
| Appearance | Yellow crystalline powder |
| Color | Beige |
| pKa | -2.26±0.36(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.5300 (estimate) |
| MDL | MFCD00007364 |
| Physical and Chemical Properties | Yellow crystalline powder |
| Use | Used as an intermediate |
2-氨基-5-硝基二苯酮 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | PC4935000 |
| HS Code | 29223990 |
2-氨基-5-硝基二苯酮 - Upstream Downstream Industry
| Raw Materials | 4-Chlorobenzoic acid |
2-氨基-5-硝基二苯酮 - Introduction
Soluble in ethanol and acetic acid, solubility: 3 MG/L water (20 C),0.21G/100 ML methanol, 0.21G/100 ML ethanol, 0.15G/100 ML isopropanol, 17G/100 ML N,N-DMF,3G/100 ML acetone, 1.5G/100 ML chloroform.
Last Update：2022-10-16 17:14:29
2-氨基-5-硝基二苯酮 - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| use | as a pharmaceutical intermediate. Used as an intermediate |
| Production method | It is obtained by condensation of p-nitroaniline and benzoyl chloride. Add p-nitroaniline, benzoyl chloride and zinc chloride into the reaction tank and stir, and heat to melt all the materials. Raise the temperature to 140 ℃ and keep the temperature for 30min. Continue to raise the temperature to about 200 ℃, hold the temperature for 2 hours, cool to 115-120 ℃, stir and hydrolyze for 15 hours. Add 2.5 times dilute hydrochloric acid, cool to 35 ℃, and filter. The filter cake is washed with dilute hydrochloric acid and filtered dry. Add 4 times the amount of water to stir into paste, add alkali to pH 11, soak for 2-3h (add alkali to pH 11 during soaking). Filter and wash the filter cake with water to make the pH 6-7. Filter and dry to obtain crude benzophenone. Add appropriate amount of activated carbon and 10 times the amount of ethanol, and heat and reflux for 4 hours. Filter while hot. The filtrate is cooled and crystallized. Filter, wash the cake with cold ethanol, filter dry, dry to get. The yield was 25%. |
Last Update：2024-04-09 02:00:07
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Raw Materials for 2-氨基-5-硝基二苯酮