2-氨苯基(4-溴苯基)甲酮
2-AMINO-4'-BROMOBENZOPHENONE
CAS: 1140-17-6
Molecular Formula: C13H10BrNO
2-氨苯基(4-溴苯基)甲酮 - Names and Identifiers
| Name | 2-AMINO-4'-BROMOBENZOPHENONE |
| Synonyms | -bromobenzophenone 2-AMINO-4'-BROMOBENZOPHENONE (2-aminophenyl)(4-bromophenyl)methanone Methanone,(2-aMinophenyl)(4-broMophenyl)- (2-amino-phenyl)-(4-bromo-phenyl)-methanone (2-AMINO-PHENYL)-(4-BROMO-PHENYL)-METHANONE |
| CAS | 1140-17-6 |
| InChI | InChI=1/C13H10BrNO/c14-10-7-5-9(6-8-10)13(16)11-3-1-2-4-12(11)15/h1-8H,15H2 |
2-氨苯基(4-溴苯基)甲酮 - Physico-chemical Properties
| Molecular Formula | C13H10BrNO |
| Molar Mass | 276.13 |
| Density | 1.484±0.06 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 103-110°C |
| Boling Point | 432.5±25.0 °C(Predicted) |
| Flash Point | 215.4°C |
| Vapor Presure | 1.11E-07mmHg at 25°C |
| pKa | -0.36±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.651 |
| Use | Application 2-amino -4 '-bromobenzophenone is an intermediate in the synthesis of organic intermediates and pharmaceutical intermediates, can be used in laboratory research and development process and chemical production process. |
2-氨苯基(4-溴苯基)甲酮 - Risk and Safety
| Risk Codes | R43 - May cause sensitization by skin contact R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9/PG 3 |
| WGK Germany | 3 |
| HS Code | 29223990 |
2-氨苯基(4-溴苯基)甲酮 - Upstream Downstream Industry
| Downstream Products | 3-DroMo-9,9'-spirobifluorene |
2-氨苯基(4-溴苯基)甲酮 - Preparation
At room temperature, 100mmol of o-aminobenzonitrile, 200mmol of p-bromophenylboronic acid, 5mmol of nickel catalyst Ni(dppe)Cl2 and 400mmol of trifluoroacetic acid were added to an appropriate amount of mixed solvent (a mixture of 1,4: 1-dioxane and water in a volume ratio of 4:1) to the reaction vessel, and then stirred and heated to 90°C, and stir.
After the reaction is over, first rotate and evaporate the reaction mixture to dry, then add sufficient amount of ethyl acetate to dissolve it, and then add an appropriate amount of saturated sodium bicarbonate aqueous solution and saturated sodium chloride aqueous solution for washing, The organic layer and the water layer are separated. After the water layer is extracted with ethyl acetate for 3 times, the organic layers are combined (that is, the organic layer after the mixed aqueous solution is combined and the organic layer, distillation under reduced pressure, the residue is eluted by rapid column chromatography (with a mixture of petroleum ether and ethyl acetate in a volume ratio of 1:0.5 as eluent), the eluent is collected and evaporated to remove the eluent, resulting in a light yellow solid 2-amino-4'-bromo-benzophenone with a yield of 86.8% and a purity of 94.6%.
Last Update：2024-04-10 22:29:15
2-氨苯基(4-溴苯基)甲酮 - Reference Information
| application | 2-amino -4 '-bromobenzobenzophenone is a Pronac intermediate, an organic synthesis intermediate and a pharmaceutical intermediate, which can be used in laboratory research and development and chemical production. |
| preparation | at room temperature, 100mmol o-aminobenzonitrile, 200mmol p-bromophenylboric acid, 5mmol nickel catalyst Ni(dppe)Cl2 and 400mmol trifluoroacetic acid are added to an appropriate amount of mixed solvent (a mixture of 1, 4-dioxane and water with a volume ratio of 4:1) in the reaction vessel, the temperature was then stirred to 90°C, and the reaction was stirred at this temperature for 24 hours. After the reaction is over, the reaction mixture is first rotated and evaporated to dry, then sufficient amount of ethyl acetate is added to dissolve it, and then an appropriate amount of saturated sodium bicarbonate aqueous solution and saturated sodium chloride aqueous solution are added for washing to separate the organic layer and the water layer. After the water layer is extracted with ethyl acetate for 3 times, the organic layer (that is, the organic layer after the mixed aqueous solution is washed and the organic layer obtained by ethyl acetate extraction) is combined, dried with anhydrous sodium sulfate, and reduced pressure Distillation, the residue was eluted by rapid column chromatography (with a mixture of petroleum ether and ethyl acetate in a volume ratio of 1:0.5 as the eluent), the eluent was collected and evaporated to remove the eluent, resulting in a light yellow solid 2-Amino -4 '-bromo-benzophenone with a yield of 86.8% and a purity of 94.6%. |
Last Update：2024-04-09 15:16:37
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View History
2-氨苯基(4-溴苯基)甲酮
TETRAPHENYLDIPHOSPHINE
DL-缬氨酸甲酯盐酸盐
3-氯-1-乙炔基苯
3-{2-[4-(Benzyloxy)phenoxy]ethyl}piperidinehydrochloride
TETRAPHENYLDIPHOSPHINE
DL-缬氨酸甲酯盐酸盐
3-氯-1-乙炔基苯
3-{2-[4-(Benzyloxy)phenoxy]ethyl}piperidinehydrochloride
Downstream Products for 2-氨苯基(4-溴苯基)甲酮