2-羧酸甲酯-5-三氟甲基吡啶

2-羧酸甲酯-5-三氟甲基吡啶 - Names and Identifiers

Name	5-TRIFLUOROMETHYL-PYRIDINE-2-CARBOXYLICACIDMETHYLESTER
Synonyms	Methyl 5-(trifluoromethyl)picolinate Methyl 5-(trifluoromethyl)picolinate METHYL 5-(TRIFLUOROMETHYL)PYRIDIN-CARBOXYLATE methyl 5-trifluoromethyl-2-pyridinecarboxylate Methyl 3-(trifluoroMethyl)-5-pyridinecarboxylate Methyl 5-(trifluoromethyl)pyridine-2-carboxylate 5-TRIFLUOROMETHYL-PYRIDINE-2-CARBOXYLICACIDMETHYLESTER 2-Pyridinecarboxylic acid,5-(trifluoromethyl)-,methyl ester 2-Pyridinecarboxylic acid,5-(trifluoromethyl)-,methyl ester
CAS	124236-37-9
InChI	InChI=1/C8H6F3NO2/c1-14-7(13)6-3-2-5(4-12-6)8(9,10)11/h2-4H,1H3

2-羧酸甲酯-5-三氟甲基吡啶 - Physico-chemical Properties

Molecular Formula	C8H6F3NO2
Molar Mass	205.13
Density	1.331±0.06 g/cm3(Predicted)
Boling Point	248.0±40.0 °C(Predicted)
Flash Point	103.8°C
Vapor Presure	0.0249mmHg at 25°C
pKa	-0.73±0.10(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.446

2-羧酸甲酯-5-三氟甲基吡啶 - Risk and Safety

Risk Codes	R22 - Harmful if swallowed R41 - Risk of serious damage to eyes
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection.
WGK Germany	3
Hazard Class	IRRITANT

2-羧酸甲酯-5-三氟甲基吡啶 - Introduction

Methyl 5-trifluoromethylpyridine-2-carboxylate, also known as TFP ester, is an organic compound. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: colorless liquid
-Molecular formula: C8H4F3NO2
-Molecular weight: 205.12g/mol
-Density: 1.374 g/mL
-Boiling Point: 164-165°C

Use:
- TFP esters are widely used in organic synthesis and pharmaceutical research. It is an effective aromatic group protecting reagent, which can be used to protect amino group, hydroxyl group and thioether group.
-It can be used as a pharmaceutical intermediate for the synthesis of organic compounds containing trifluoromethyl groups.
-In addition, TFP ester can also be used for the synthesis of amide compounds, and is widely used in chemical, pharmaceutical and pesticide research for ester exchange reactions and amino protection.

Preparation Method:
- TFP esters can be prepared by reacting trifluoromethylpyridine with methyl 2-formate. The reaction usually takes place at room temperature and the desired product can be purified by distillation.

Safety Information:
- TFP ester is considered safe under normal conditions of use. However, as an organic compound, it has a certain potential danger.
-Direct contact with skin and eyes may cause irritation or injury. Therefore, care should be taken to wear appropriate protective equipment such as gloves and goggles during use.
-In addition, TFP ester should also be kept away from fire and high temperature to avoid possible fire or explosion.

For more specific use and safety information, please consult the relevant chemical literature or consult a professional.

Last Update：2024-04-09 20:52:54