20-trione,17,21-dihydroxy-pregn-4-ene-11
cortisone
CAS: 53-06-5
Molecular Formula: C21H28O5
20-trione,17,21-dihydroxy-pregn-4-ene-11 - Names and Identifiers
| Name | cortisone |
| Synonyms | Corlin Adreson Andreson Adrenalex Cortadren cortisone 20-trione,17,21-dihydroxy-pregn-4-ene-11 17,21-dihydroxypregn-4-ene-3,11,20-trione 17,21-Dihydroxy-4-pregnene-3,11,20-trione 17,21-Dihydroxypregn-4-ene-3,11,20-trione 17-alpha,21-dihydroxypregn-4-ene-3,11,20-trione (8xi,9xi,14xi)-17,21-dihydroxypregn-4-ene-3,11,20-trione |
| CAS | 53-06-5 |
| EINECS | 200-162-4 |
| InChI | InChI=1/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14?,15?,18?,19-,20-,21-/m0/s1 |
20-trione,17,21-dihydroxy-pregn-4-ene-11 - Physico-chemical Properties
| Molecular Formula | C21H28O5 |
| Molar Mass | 360.44 |
| Density | 1.28±0.1 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 223-228°C (dec.)(lit.) |
| Boling Point | 412.46°C (rough estimate) |
| Specific Rotation(α) | D25 +209° (c = 1.2 in 95% alcohol); 25546 +269° (c = 0.125 in benzene); 25546 +248° (c = 0.1 to 0.2 |
| Flash Point | 9℃ |
| Water Solubility | 229.9mg/L(25 ºC) |
| Solubility | 100 μg/mL in methanol |
| Vapor Presure | 2.96E-15mmHg at 25°C |
| Appearance | White to Off-White Solid |
| Color | White to Pale Beige |
| Merck | 2539 |
| pKa | 12.37±0.60(Predicted) |
| Storage Condition | -20°C Freezer |
| Refractive Index | 210 ° (C=1, EtOH) |
| MDL | MFCD00003610 |
| Physical and Chemical Properties | White crystalline powder. Mp220-224 ° C (partial decomposition), specific optical rotation [α]25D +209 °(1.2%,95% ethanol), [α]25546+269 °(0.125%, benzene). Soluble in methanol, ethanol, acetone; Slightly soluble in ether, chloroform and benzene; Difficult to dissolve in water, aqueous solution was neutral. In concentrated sulfuric acid was orange red, and green fluorescence. |
| Use | For the adrenal cortex hormone drugs, suitable for the treatment of active rheumatism, rheumatoid arthritis, allergic dermatitis and allergic malignant conjunctivitis and other diseases |
| In vitro study | Cortisone (2.8-28,000 nM) dose-dependently attenuates the apoptosis induced by Cortisol in peripheral-blood mononuclear cells (PBMCs). |
20-trione,17,21-dihydroxy-pregn-4-ene-11 - Risk and Safety
| Risk Codes | R11 - Highly Flammable R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R39/23/24/25 - R63 - Possible risk of harm to the unborn child |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
| UN IDs | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | GM9020000 |
| FLUKA BRAND F CODES | 18 |
| HS Code | 2937210000 |
20-trione,17,21-dihydroxy-pregn-4-ene-11 - Reference
| Reference Show more | 1. [IF=7.711] Rong Zhang et al."A Disposable Printed Liquid Gate Graphene Field Effect Transistor for a Salivary Cortisol Test."Acs Sensors. 2021;6(8):3024–3031 |
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