200134-22-1
1-(4-ethylphenyl)-3-phenylurea
CAS: 200134-22-1
Molecular Formula: C15H16N2O
200134-22-1 - Names and Identifiers
| Name | 1-(4-ethylphenyl)-3-phenylurea |
| Synonyms | INH14 1-(4-ethylphenyl)-3-phenylurea N-(4-Ethylphenyl)-N'-phenylurea Urea, N-(4-ethylphenyl)-N'-phenyl- |
| CAS | 200134-22-1 |
200134-22-1 - Physico-chemical Properties
| Molecular Formula | C15H16N2O |
| Molar Mass | 240.3 |
| Density | 1.185±0.06 g/cm3(Predicted) |
| Boling Point | 296.4±19.0 °C(Predicted) |
| Solubility | soluble in DMSO |
| pKa | 14.46±0.70(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Use | INH14 is an inhibitor of IKKα/IKKβ with IC50 values of 8.97 and 3.59 μM, respectively. INH14 inhibits the IKKα/β-dependent TLR inflammatory response. Inhibit the downstream and NF-kB signaling pathways of TAK1/TAB1. It has anti-inflammatory and anti-cancer effects. |
200134-22-1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.161 ml | 20.807 ml | 41.615 ml |
| 5 mM | 0.832 ml | 4.161 ml | 8.323 ml |
| 10 mM | 0.416 ml | 2.081 ml | 4.161 ml |
| 5 mM | 0.083 ml | 0.416 ml | 0.832 ml |
Last Update：2024-01-02 23:10:35
200134-22-1 - Reference Information
| biological activity | INH14 is an inhibitor of TLR2-mediated NF-kB activation, the IC50 values for ikkα and IKKβ were 8.975 μm and 3.598 μm, respectively. |
| Target | Value |
| NF-κB () | |
| IKKβ () | 3.598 μM |
| IKKα () | 8.975 μM |
| Animal Model: | 8-week old, male, pathogen-free C57BL/6J mice |
| Dosage: | 5 µg/g, one hour before Pam2CSK4 injection |
| Administration: | I.P. for 2 hours |
| Result: | Decreased TNFα production in mice. |
Last Update：2024-04-10 22:29:15
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Product Name: 1-(4-ethylphenyl)-3-phenylurea Visit Supplier Webpage Request for quotationCAS: 200134-22-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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