Molecular Formula | C20H29N2NaO11S
|
Molar Mass | 528.51 |
Solubility | Soluble in DMSO (up to 20 mg/ml). |
Appearance | White solid. |
Color | White |
Storage Condition | Sealed in dry,Room Temperature |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months |
In vitro study | Sivelestat inhibits neutrophil migration and adhesion to endothelial cells. |
In vivo study | In a newborn piglet model, siverlestat effectively reduced neutrophil induction and activation in the lungs and improved oxidation after cardiopulmonary bypass. By inhibiting neutrophil elastase, sivelestat has a direct effect on accumulating, activated leukocytes, effectively protecting leukocytes against the production of oxygen free radicals and cytokines. |