20362-31-6
arctiin
CAS: 20362-31-6
Molecular Formula: C27H34O11
20362-31-6 - Names and Identifiers
20362-31-6 - Physico-chemical Properties
| Molecular Formula | C27H34O11 |
| Molar Mass | 534.55 |
| Density | 1.363±0.06 g/cm3(Predicted) |
| Melting Point | 107.0 to 111.0 °C |
| Boling Point | 756.4±60.0 °C(Predicted) |
| Specific Rotation(α) | -53.2 °(c=0.0l9，methanol) |
| Flash Point | 250.1°C |
| Solubility | Soluble in chloroform, methanol and other organic solvents |
| Vapor Presure | 4.79E-24mmHg at 25°C |
| Appearance | White cluster needle crystal (95% ethanol) |
| Color | White to Off-White |
| Maximum wavelength(λmax) | ['278nm(EtOH)(lit.)'] |
| pKa | 12.83±0.70(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.6 |
| MDL | MFCD00870630 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, derived from fructus arctii, forsythia suspensa, plowstone Vine. |
| In vitro study | Arctiin induces growth inhibition and dephosphorylation of the tumor suppressor rb protein (retinoblastoma protein) in human immortalized keratinocytes HaCaT. Arctiin inhibits cell growth by down-regulating cyclin D1 protein levels. arctiin-induced inhibition of cyclin D1 protein expression exists in a variety of human tumor cells, including osteosarcoma, lung cancer, colon cancer, cervical cancer, melanoma, transformed renal cells and prostate cancer. |
| In vivo study | Arctiin has anticancer activity in animal models. In the two-stage carcinogenic test of mouse skin tumor model, it has significant anti-tumor effect. At the tumor-promoting stage, Arctiin has a protective effect against PhIP-induced carcinogenesis, especially in the mammary gland. Arctiin was shown to be effective orally in both IFV-inoculated normal mice and 5-FU-treated mice. |
20362-31-6 - Risk and Safety
| WGK Germany | 3 |
| HS Code | 29389090 |
20362-31-6 - Reference
| Reference Show more | 1. Zhou Fei, Hu Rong, Liu Chenjie, et al. Comparison of Pancreatic Lipase Activity Inhibitory by Different Forsythia Suspensa Leaves [J]. Journal of Shanxi University (Natural Science Edition), 2018, v.41;No.160(02):161-167. 2. Xu Lin, Song Jian, Feng Yu, Zhang Huimin. UPLC Simultaneous Determination of 8 Components in Yinqiao Powder with Different Particle Sizes [J]. Journal of Shandong University of Traditional Chinese Medicine, 2021,45(02):249-255. 3. Xu Lin, Song Jian, Feng Yu, Zhang Huimin, Wang Ping. Orthogonal Experimental Study on Ultramicro and Constant Temperature Extraction of Yinqiao Powder [J]. Shi Zhen, Chinese medicine, 2020,31(09):2127-2130. 4. Valkó, Klára. "Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https://doi.org/10.1016/j.chroma. 2003.10.084 5. Valkó, Klára. "Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https://doi.org/10.1016/j.chroma. 2003.10.084 6. [IF=4.411] Jifeng Gu et al."Application of High-Performance Liquid Chromatography Coupled with Linear Ion Trap Quadrupole Orbitrap Mass Spectrometry for Qualitative and Quantitative Assessment of Shejin-Liyan Granule Supplements."Molecules. 2018 Apr;23(4):884 7. [IF=4.486] Xiang Xu et al."Antidepressive Effect of Arctiin by Attenuating Neuroinflammation via HMGB1/TLR4- and TNF-α/TNFR1-Mediated NF-κB Activation."Acs Chem Neurosci. 2020;11(15):2214-2230 8. [IF=3.411] Zhou Yuyan et al."Arctiin Antagonizes Triptolide-Induced Hepatotoxicity via Activation of Nrf2 Pathway."Biomed Res Int. 2020;2020:2508952 9. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 10. [IF=3.269] Ziye Liu et al."Arctiin elevates osteogenic differentiation of MC3T3-E1 cells by modulating cyclin D1."Bioengineered. 2022;13(4):10866-10874 |
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