203866-16-4

203866-16-4 - Names and Identifiers

Name	1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate
Synonyms	N-Boc-cis-4-Fluoro-L-proline methyl ester N-t-BOC-cis-4-fluoro-L-proline methyl ester Ethyl (2S,4S)-1-Boc-4-fluoropyrrolidine-2-carboxylate N-(tert-Butoxycarbonyl)-(2S,4S)-4-fluoroproline Methyl ester (2S)-1-tert-butyl 2-methyl 4-fluoropyrrolidine-1,2-dicarboxylate 1-tert-butyl 2-Methyl (2S,4S)-4-fluoro-1,2-pyrrolidinedicarboxylate 1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate (2S,4S)-4-Fluoro-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) 2-methyl ester
CAS	203866-16-4
InChI	InChI=1/C11H18FNO4/c1-11(2,3)17-10(15)13-6-7(12)5-8(13)9(14)16-4/h7-8H,5-6H2,1-4H3/t7-,8-/m0/s1
InChIKey	METPQQHVRNLTRX-YUMQZZPRSA-N

203866-16-4 - Physico-chemical Properties

Molecular Formula	C11H18FNO4
Molar Mass	247.26
Density	1.153
Melting Point	210 °C
Boling Point	296.5±40.0 °C(Predicted)
Specific Rotation(α)	-67o (C=0.5 IN METHANOL)
Flash Point	110℃
Vapor Presure	0.001mmHg at 25°C
pKa	-5.68±0.60(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.448

203866-16-4 - Risk and Safety

WGK Germany

203866-16-4 - Introduction

1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate is a common compound in organic synthesis, and its chemical formula is C12H18FNO4. The following is a description of some properties, uses, preparation and safety information about this compound:

Nature:
1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate is a colorless to light yellow solid with a low melting point and boiling point. It is stable at room temperature, but may decompose under high temperature and strong acid conditions.

Use:
1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate is widely used in organic synthesis, especially in the field of peptide synthesis. It is often used as a protecting group to protect amine groups in amino acids to prevent unwanted changes in synthetic reactions. In addition, it can also be used as an important synthetic intermediate for the preparation of other related compounds.

Method:
1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate is usually prepared by chemical synthesis. A common method is to use boc-cis-4-fluoro-l-proline as the starting material to obtain the desired product by esterification reaction with methyl formate under basic conditions.

Safety Information:
When using or handling 1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate, note the following safety precautions:
1. Avoid contact with skin, eyes and respiratory tract, and wear appropriate protective equipment during use.
2. During operation, Good Laboratory safety practices should be observed to ensure good ventilation conditions.
3. Avoid the compound and combustible, strong oxidant and strong acid and other substances contact, to prevent dangerous reaction.
4. When storing, the compound should be sealed and stored in a cool, dry place, away from fire and heat sources.
5. When disposing of waste, it should be properly disposed of in accordance with local regulations.

Please note that this is only a general introduction to 1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate, the specific operation and use details should be further understood and implemented according to the actual situation and relevant literature.

Last Update：2024-04-10 22:29:15