204326-43-2
NS-2028
CAS: 204326-43-2
Molecular Formula: C9H5BrN2O3
204326-43-2 - Names and Identifiers
204326-43-2 - Physico-chemical Properties
| Molecular Formula | C9H5BrN2O3 |
| Molar Mass | 269.05 |
| Density | 2.06±0.1 g/cm3(Predicted) |
| Melting Point | 160～170℃ |
| Boling Point | 353.8±52.0 °C(Predicted) |
| Solubility | DMSO: 13mg/mL |
| Appearance | solid |
| Color | white |
| pKa | -1.18±0.20(Predicted) |
| Storage Condition | +2C to +8C |
204326-43-2 - Risk and Safety
| WGK Germany | 3 |
204326-43-2 - References
| biological activity | NS-2028 is a highly selective soluble guanylate cyclase (sGC) inhibitor, the IC50 values for the basal and NO-stimulated enzymatic activities were 30 nM and 200 nM, respectively. NS-2028 inhibition of soluble guanylate cyclase activity in mouse cerebellar homogenate and neuronal NO synthase, IC50 values were 17 nM and 20 nM. NS-2028 inhibition of 3-morpholino-sydnonimine (SIN-1) formation of cyclic GMP in cultured human umbilical vein endothelial cells with an IC50 value of 30 nM. NS-2028 is commonly used in the study of Nitric oxide signaling pathway, which completely inhibits the NO-dependent relaxation response (1 μm) in non-vascular smooth muscle. NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability. |
| Target | IC50: 30 nM |
| Cell Line: | HUVEC cells HUVEC cells |
| Concentration: | 10 μM 10 μM |
| Incubation Time: | 24 hours 30 mins |
| Result: | Decreased cell numbers in culture. Attenuated VEGF-enhanced p38 phosphorylation. Inhibits VEGF-induced angiogenesis in vivo. |
| Animal Model: | Rabbit |
| Dosage: | 1 g/L |
| Administration: | Deliver orally; 1g/L; 8 days |
Last Update：2024-04-09 21:21:28
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View History
204326-43-2
3-(CYANOMETHYL)-1-(4-METHOXYPHENYL)-4-{[(4-METHOXYPHENYL)AMINO]CARBONYL}-1H-1,2,3-TRIAZOL-3-IUM-5-OLATE
5-溴-4-甲基-2(1H)-吡啶酮
2-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-ol
D90108
三苯甲烷标准品
2-[4-(4-Chlorobenzyl)phenoxy]-2-methylbutyric acid ethyl ester
bis[(tetrahydrofuran-2-yl)methyl] phthalate
Pyrenyl-1-boronic acid pinacol ester
3,4-Dihydroxybenzophenone
3-(CYANOMETHYL)-1-(4-METHOXYPHENYL)-4-{[(4-METHOXYPHENYL)AMINO]CARBONYL}-1H-1,2,3-TRIAZOL-3-IUM-5-OLATE
5-溴-4-甲基-2(1H)-吡啶酮
2-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-ol
D90108
三苯甲烷标准品
2-[4-(4-Chlorobenzyl)phenoxy]-2-methylbutyric acid ethyl ester
bis[(tetrahydrofuran-2-yl)methyl] phthalate
Pyrenyl-1-boronic acid pinacol ester
3,4-Dihydroxybenzophenone