20434-05-3 - Names and Identifiers
20434-05-3 - Physico-chemical Properties
Molecular Formula | C14H15O4P
|
Molar Mass | 278.24 |
Melting Point | 185-187°C(lit.) |
Solubility | DMSO (Slightly), Methanol (Slightly) |
Appearance | Solid |
Color | White to Off-White |
Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
20434-05-3 - Risk and Safety
20434-05-3 - Introduction
Bis (4-methoxyphenyl) phosphinic acid (also known as bis (4-methoxyphenyl) phosphonic acid) is an organic compound with the chemical formula C15H17O4P. It is an organic phosphoric acid with the following characteristics and properties:
1. Appearance: Bis (4-methoxyphenyl) phosphinic acid is a white solid, sometimes light yellow.
2. solubility: it can be dissolved in water, and can be dissolved in organic solvents such as ethanol, ether, etc.
3. Stability: Under standard conditions, bis (4-methoxyphenyl) phosphinic acid has good chemical stability and can be stored at room temperature.
In terms of use, bis (4-methoxyphenyl) phosphinic acid is mainly used in the field of organic synthesis, as a catalyst or ligand to participate in various important organic reactions. It plays an important role in metal-catalyzed C- C bond formation and C- X bond formation reactions, and is widely used in organic synthesis and pharmaceutical research.
The method for preparing bis (4-methoxyphenyl) phosphinic acid can be achieved by esterification of phenyl ether phosphonic acid. A common method is to react p-methoxyphenylchlorophosphine (C6H4(OCH3)PCl) with tert-butyl phosphite under base to give bis (4-methoxyphenyl) phosphinic acid.
When using bis (4-methoxyphenyl) phosphinic acid, it is necessary to pay attention to safety matters and handling requirements. Although it is relatively stable at room temperature, exposure to open flames and high temperatures should be avoided to prevent possible dangerous reactions. In addition, appropriate personal protective equipment, such as laboratory gloves and protective glasses, should be worn during operation to reduce the risk of exposure and inhalation.
Last Update:2024-04-09 20:52:54