20445-31-2
(R)-(+)-A-methoxy-A-(trifluoromethyl)phenylacetic acid
CAS: 20445-31-2
Molecular Formula: C10H9F3O3
20445-31-2 - Names and Identifiers
| Name | (R)-(+)-A-methoxy-A-(trifluoromethyl)phenylacetic acid |
| Synonyms | (+)MTPA (+)-Moshers acid (+)-Moshers acid~(+)-MTPA (R)-(+)-MTPA,(R)-(+)-Mosher'sacid (R)-(+)-A-methoxy-A-(trifluoromethyl)phenylacetic acid (r)-(+)-à-methoxy-à-(trifluoromethyl)phenylacetic acid (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl chloride (R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid (+)--Methoxy--(trifluoromethyl)phenylaceticacid(Moshersacid) (R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid (R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Acid [Optical Resolving] |
| CAS | 20445-31-2 |
| EINECS | 243-829-5 |
| InChI | InChI=1/C10H8ClF3O2/c1-16-9(8(11)15,10(12,13)14)7-5-3-2-4-6-7/h2-6H,1H3/t9-/m0/s1 |
20445-31-2 - Physico-chemical Properties
| Molecular Formula | C10H9F3O3 |
| Molar Mass | 234.17 |
| Density | 1.344g/mLat 25°C(lit.) |
| Melting Point | 46-49°C(lit.) |
| Boling Point | 105-107°C1mm Hg(lit.) |
| Specific Rotation(α) | D25 +68.5 ± 1.3° (c = 1.49 in CH3OH) |
| Flash Point | >230°F |
| Solubility | Soluble in methanol (50 mg/ 1 ml). |
| Vapor Presure | 0.164mmHg at 25°C |
| Appearance | Crystalline Low Melting Solid |
| Specific Gravity | 1.344 |
| Color | White |
| Merck | 14,6280 |
| BRN | 2215440 |
| pKa | 1.47±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | Hygroscopic |
| Refractive Index | n20/D 1.473(lit.) |
| MDL | MFCD00004184 |
| Use | A derivatizing reagent used for the determination of enantiomeric excess by NMR. |
20445-31-2 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 3-10 |
| HS Code | 29189900 |
| Hazard Note | Irritant/Keep Cold |
| Hazard Class | IRRITANT, HYGROSCOPI |
20445-31-2 - Introduction
(R)-( )-A-methoxy-A-(trifluoromethyl)phenylacetic acid, chemical formula C10H9F3O3, is an organic compound.
properties:(R)-( )-A-methoxy-A-(trifluoromethyl)phenylacetic acid is a white crystalline solid with special optical activity and optical rotation. It is soluble in common organic solvents at room temperature, such as alcohols, ethers, etc.
Purpose:(R)-( )-A-methoxy-A-(trifluoromethyl)phenylacetic acid is an important chiral drug intermediate. It can be used as a raw material for the synthesis of drugs, especially in the preparation of chiral drugs has important application value.
preparation method:(R)-( )-A-methoxy-A-(trifluoromethyl)phenylacetic acid is relatively complicated and generally requires multi-step reactions to synthesize. Common preparation methods include asymmetric synthesis and chiral group transfer reactions.
Safety Information:(R)-( )-A-methoxy-A-(trifluoromethyl)phenylacetic acid generally has good stability and safety under normal use conditions. But like other chemicals, it still needs to be handled and stored properly. During use, care should be taken to avoid contact with skin and eyes. If contact occurs, rinse with water immediately and seek medical help. At the same time, the relevant laboratory practices and safety guidelines should be strictly observed.
properties:(R)-( )-A-methoxy-A-(trifluoromethyl)phenylacetic acid is a white crystalline solid with special optical activity and optical rotation. It is soluble in common organic solvents at room temperature, such as alcohols, ethers, etc.
Purpose:(R)-( )-A-methoxy-A-(trifluoromethyl)phenylacetic acid is an important chiral drug intermediate. It can be used as a raw material for the synthesis of drugs, especially in the preparation of chiral drugs has important application value.
preparation method:(R)-( )-A-methoxy-A-(trifluoromethyl)phenylacetic acid is relatively complicated and generally requires multi-step reactions to synthesize. Common preparation methods include asymmetric synthesis and chiral group transfer reactions.
Safety Information:(R)-( )-A-methoxy-A-(trifluoromethyl)phenylacetic acid generally has good stability and safety under normal use conditions. But like other chemicals, it still needs to be handled and stored properly. During use, care should be taken to avoid contact with skin and eyes. If contact occurs, rinse with water immediately and seek medical help. At the same time, the relevant laboratory practices and safety guidelines should be strictly observed.
Last Update：2024-04-09 21:11:58
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Tel: +86-18821248368
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