206658-92-6
Tacrine HCl hydrate
CAS: 206658-92-6
Molecular Formula: C13H17ClN2O
206658-92-6 - Names and Identifiers
| Name | Tacrine HCl hydrate |
| Synonyms | Tacrine HCl hydrate |
| CAS | 206658-92-6 |
206658-92-6 - Physico-chemical Properties
| Molecular Formula | C13H17ClN2O |
| Molar Mass | 252.73988 |
| Melting Point | 284-286°C (lit.) |
| Solubility | H2O: soluble |
| Storage Condition | 2-8℃ |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | Tacrine hydrochloride hydrate (12.5 to 37.5 nM) inhibits venom acetylcholinesterase as well as human serum butyrylcholinesterase in a concentration-dependent manner. The IC 50 is 31 nM for snake venom AChE and 25.6 nM for human BChE. |
| In vivo study | Pretreatment with Tacrine hydrochloride hydrate also modifies absolute levels of cocaine self-administration during reacquisition. Body weight declines approximately one-half percent over four days of treatment with intravenous Tacrine hydrochloride hydrate. Delivery of Tacrine hydrochloride hydrate by osmotic pump does not alter either linear- or repeated- cocaine-induced locomotor activity. There is no significant main effect or interaction with Tacrine hydrochloride hydrate treatment on active lever responding during reinstatement. Post hoc comparisons indicate that rats self-administering cocaine has significantly lower alkaline phosphatase levels, relative to Tacrine hydrochloride hydrate- but not saline- treated rats evaluated by conditioned-place preference. |
206658-92-6 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R40 - Limited evidence of a carcinogenic effect |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
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Multiple Specifications
Product Name: Tacrine HCl hydrate Visit Supplier Webpage Request for quotationCAS: 206658-92-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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