2070015-10-8
ML204 HYDROCHLORIDE
CAS: 2070015-10-8
Molecular Formula: C15H19ClN2
2070015-10-8 - Names and Identifiers
| Name | ML204 HYDROCHLORIDE |
| Synonyms | ML 204 ML204 HYDROCHLORIDE |
| CAS | 2070015-10-8 |
2070015-10-8 - Physico-chemical Properties
| Molecular Formula | C15H19ClN2 |
| Molar Mass | 262.78 |
| Solubility | H2O : 30 mg/mL (114.16 mM) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| In vitro study | ML204 hydrochloride inhibits TRPC4β-mediated intracellular Ca 2+ rise with an IC 50 value of 0.96 μM (HEK293 cells) and exhibits 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation. ML204 hydrochloride blocks TRPC4β activity induced through either G i/o stimulation by μ-opioid, 5HT 1A serotonin, and M 2 muscarinic receptors or G q/11 stimulation by the endogenous M 3 -like muscarinic receptors. ML204 hydrochloride blocks LPS-induced TRPC5 channel activity. |
| In vivo study | ML204 hydrochloride (1 mg/kg; s.c.; twice a day; for 5 days) causes mortality associated with exacerbated hypothermia and decreases peritoneal leukocyte numbers and cytokines in LPS-injected mice. Animal Model: Nonfasted male C57BL/6 (2-3 months) Dosage: 1 mg/kg Administration: Subcutaneous injection, twice a day, for 5 days (prior to LPS injection) Result: Induces mortality associated with increased hypothermia in mice with LPS-induced systemic inflammatory response. |
2070015-10-8 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.805 ml | 19.027 ml | 38.055 ml |
| 5 mM | 0.761 ml | 3.805 ml | 7.611 ml |
| 10 mM | 0.381 ml | 1.903 ml | 3.805 ml |
| 5 mM | 0.076 ml | 0.381 ml | 0.761 ml |
Last Update：2024-01-02 23:10:35
2070015-10-8 - Introduction
ML204 HYDROCHLORIDE is a small organic molecule compound with the chemical name N-[2-Methyl-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]-2-(trifluoromethyl)benzamide. It has the form of a white crystalline solid.
ML204 HYDROCHLORIDE is mainly used as a research compound for pharmacological and biochemical applications, especially in the field of neuroscience. It is widely used to study the role of ion channels, receptors and transporters in cell function.
The method of preparing ML204 HYDROCHLORIDE is usually a multi-step synthetic route. In short, its synthetic steps include the reaction of benzoyl chloride and 2-amino -4-(trifluoromethyl) thiophenol to obtain an intermediate, which is then reacted by aminomethylation, the amidation reaction and chlorination reaction are the final products.
When using ML204 HYDROCHLORIDE, you need to pay attention to some safety information. It belongs to organic compounds and has certain toxicity and irritation. During handling and handling in the laboratory, wear appropriate protective equipment, such as gloves and glasses, to avoid contact with skin and eyes. In addition, it should be operated in a well-ventilated place to prevent the inhalation of its vapor. When storing and handling ML204 HYDROCHLORIDE, keep it in a closed container, away from fire and oxidizing agents.
ML204 HYDROCHLORIDE is mainly used as a research compound for pharmacological and biochemical applications, especially in the field of neuroscience. It is widely used to study the role of ion channels, receptors and transporters in cell function.
The method of preparing ML204 HYDROCHLORIDE is usually a multi-step synthetic route. In short, its synthetic steps include the reaction of benzoyl chloride and 2-amino -4-(trifluoromethyl) thiophenol to obtain an intermediate, which is then reacted by aminomethylation, the amidation reaction and chlorination reaction are the final products.
When using ML204 HYDROCHLORIDE, you need to pay attention to some safety information. It belongs to organic compounds and has certain toxicity and irritation. During handling and handling in the laboratory, wear appropriate protective equipment, such as gloves and glasses, to avoid contact with skin and eyes. In addition, it should be operated in a well-ventilated place to prevent the inhalation of its vapor. When storing and handling ML204 HYDROCHLORIDE, keep it in a closed container, away from fire and oxidizing agents.
Last Update：2024-04-09 19:05:03
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Product Name: ML204 HYDROCHLORIDE Visit Supplier Webpage Request for quotation
CAS: 2070015-10-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 2070015-10-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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