2081072-29-7
NEO2734
CAS: 2081072-29-7
Molecular Formula: C22H24F3N3O3
2081072-29-7 - Names and Identifiers
| Name | NEO2734 |
| Synonyms | EP31670 NEO2734 |
| CAS | 2081072-29-7 |
2081072-29-7 - Physico-chemical Properties
| Molecular Formula | C22H24F3N3O3 |
| Molar Mass | 435.44 |
| Solubility | ( < 1 mg/ml refers to the product slightly soluble or insoluble) |
| Storage Condition | -20℃ |
| Use | NEO2734 (EP31670) is a selective inhibitor of p300/CBP and BET bromodomain with oral activity, and its IC50 value is <30 nM. NEO2734 is active in both SPOP mutant and wild-type prostate cancer models. |
| Target | p300/CBP; BET bromodomain |
2081072-29-7 - Reference
| Reference Show more | 1. The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer2. Chevaun D Morrison-Smit, et al. Combined Targeting of the BRD4-NUT-p300 Axis in NUT Midline Carcinoma by Dual Selective Bromodomain Inhibitor, NEO2734. Mol Cancer Ther. 2020 Jul;19(7):1406-1414. |
2081072-29-7 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0 ml | 0 ml | 0 ml |
| 5 mM | 0 ml | 0 ml | 0 ml |
| 10 mM | 0 ml | 0 ml | 0 ml |
| 5 mM | 0 ml | 0 ml | 0 ml |
Last Update：2024-01-02 23:10:35
2081072-29-7 - Reference Information
| biological activity | NEO2734 (EP31670) is a new, orally Active selective dual inhibitors of p300/CBP and BET bromodomain both correspond to IC50 values <30 nM. |
| Target | TargetValue p300/CBP (Cell-free assay) <30 nM BET (Cell-free assay) <30 nM |
| Target | Value |
| p300/CBP (Cell-free assay) | <30 nM |
| BET (Cell-free assay) | <30 nM |
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: NEO2734 Visit Supplier Webpage Request for quotationCAS: 2081072-29-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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