209467-52-7
Ceftobiprole
CAS: 209467-52-7
Molecular Formula: C20H22N8O6S2
209467-52-7 - Names and Identifiers
| Name | Ceftobiprole |
| Synonyms | CS-734 Ceftobiprole 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2Z)-2-(5-aMino-1,2,4-thiadiazol-3-yl)-2-(hydroxyiMino)acetyl]aMino]-8-oxo-3-[(E)-[(3'R)-2-oxo[1,3'-bipyrrolidin]-3-ylidene]Methyl]-,(6R,7R)- |
| CAS | 209467-52-7 |
209467-52-7 - Physico-chemical Properties
| Molecular Formula | C20H22N8O6S2 |
| Molar Mass | 534.576 |
| Density | 2.00±0.1 g/cm3(Predicted) |
| Storage Condition | 2-8℃ |
| Physical and Chemical Properties | Bioactive Ceftobiprole (Ro 63-9141) is a broad-spectrum cephalosporin effective against methicillin-resistant Staphylococcus aureus (MRSA) with a MIC90 value of 2 μg/mL. |
209467-52-7 - Recent advances in the synthesis of cefpirome
from hownet
Author:
Li Xiaokang , Shasha Wu , Zhang Yong
Abstract:
cefpiroxil is a broad-spectrum cephalosporin antibiotic with broad application prospects, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Staphylococcus aureus (VR-SA), belong to the "fifth generation" cephalosporin antibiotics. The synthetic methods are introduced.
Key words:
cephalosporin cefpirome p synthetic route
DOI:
10.3969/j.issn.1003-5059.2012.04.011
cited:
year:
2012
Last Update：2024-01-02 23:10:35
209467-52-7 - Synthesis method of side-chain acid of cefpiroxil
from Palm Bridge research
Application (patent) number:
CN201811129772.X
application date:
2018-09-27
Public/Announcement Number:
CN109096224A
Public/announcement date:
2018.12.28
applicant (patent):
Shaanxi Sier Biotechnology Co., Ltd.
inventor:
National and provincial code:
CN610113
Abstract:
The invention discloses a synthesis method of an important antibiotic intermediate cefpiriptin side chain acid, which oximates malononitrile with sodium nitrite under the action of acetic acid, then etherification with triphenylchloromethane under alkaline action, followed by amidation under the action of concentrated ammonia, then ring with potassium thiocyanate, and finally hydrolyze with sodium hydroxide to obtain the corresponding (Z)2(5 amino 1,2,4 thiadiazole 3 YL) 2 triphenyloxyiminoacetic acid. The invention has the advantages of fewer synthetic steps, low cost, low cost and easy availability of various materials, which is beneficial to industrial production and less pollution.
Last Update：2023-08-16 22:05:47
209467-52-7 - Cefpiraprazole derivatives as prodrugs and preparation method and use thereof
Application (patent) number:
CN 201410114280
applicant (patent):
China Resources Secco Pharmaceutical Co., Ltd.
inventor:
Wang Wenfeng , Yang Min , Li Ridong
Abstract:
The present invention provides a derivative of cefpidium of formula I, a pharmaceutically acceptable salt thereof, a readily hydrolysable ester thereof, a hydrate or solvate thereof, wherein R1 and R2 respectively have the meanings defined in the specification; In addition, the present invention also relates to a process for the preparation of a compound of formula I; The compound can be used for the treatment and prevention of infectious diseases, especially infectious diseases caused by bacterial pathogens, especially methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa.
Last Update：2023-08-16 22:05:47
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