| biological activity | DBCO-NHCO-PEG4-NHS ester is a PROTAC connection bridge, belonging to PEG class and Alkyl/ether class. DBCO-NHCO-PEG4-NHS ester can be used to synthesize a series of PROTAC molecules. DBCO-NHCO-PEG4-NHS ester is a degradable (cleavable) ADC link bridge for the synthesis of antibody drug conjugates (ADCs). |
| target | Cleavable PEGs Alkyl/ether |
| in vitro research | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
