Molecular Formula | C22H29ClN2O4S |
Molar Mass | 452.99 |
Density | 1?+-.0.06 g/cm3(Predicted) |
Solubility | Soluble in DMSO |
Appearance | powder |
Color | white to beige |
pKa | 4.67±0.10(Predicted) |
Storage Condition | room temp |
Use | CP-424174 is a cytokine release inhibitory drug (CRID) (IC50 = 210 nM).CP-424174 inhibits the post-translational processing and secretion of IL-1b in response to LPS and ATP in human monocytes. |
Reference Show more | 1: Perregaux DG, McNiff P, Laliberte R, Hawryluk N, Peurano H, Stam E, Eggler J,Griffiths R, Dombroski MA, Gabel CA. Identification and characterization of anovel class of interleukin-1 post-translational processing inhibitors. JPharmacol Exp Ther. 2001 Oct;299(1):187-97. PubMed PMID: 11561079. 2: Perregaux DG, Bhavsar K, Contillo L, Shi J, Gabel CA. Antimicrobial peptidesinitiate IL-1 beta posttranslational processing: a novel role beyond innateimmunity. J Immunol. 2002 Mar 15;168(6):3024-32. PubMed PMID: 11884475. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.208 ml | 11.038 ml | 22.075 ml |
5 mM | 0.442 ml | 2.208 ml | 4.415 ml |
10 mM | 0.221 ml | 1.104 ml | 2.208 ml |
5 mM | 0.044 ml | 0.221 ml | 0.442 ml |