21190-88-5

21190-88-5 - Names and Identifiers

Name	6-Bromopyridine-2-carboxylic acid ethyl ester
Synonyms	RARECHEM AL BI 0899 Ethyl 6-bromopicolinate ETHYL 6-BROMOPICOLINATE Ethyl-6-bromopicolinate ETHYL-6-BROMO-2-PYRIDINECARBOXYLATE Ethyl 6-bromopyridine-2-carboxylate 6-BROMOPYRIDINE-2-ETHYL CARBOXYLATE ETHYL 6-BROMOPYRIDINE-2-CARBOXYLATE Ethyl 6-bromo-2-piperidinecarboxylate 6-Bromopyridine-2-carboxylic acid ethyl ester 6-BROMOPYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER 6-bromo-pyridine-2-carboxylic acid ethyl ester 2-Pyridinecarboxylic acid, 6-bromo-, ethyl ester Ethyl 6-bromopicolinate, 2-Bromo-6-(ethoxycarbonyl)pyridine
CAS	21190-88-5
EINECS	673-818-4
InChI	InChI=1/C8H8BrNO2/c1-2-12-8(11)6-4-3-5-7(9)10-6/h3-5H,2H2,1H3

21190-88-5 - Physico-chemical Properties

Molecular Formula	C8H8BrNO2
Molar Mass	230.06
Density	1.501±0.06 g/cm3(Predicted)
Melting Point	41-42°C
Boling Point	302.7±22.0 °C(Predicted)
Flash Point	136.9°C
Vapor Presure	0.000973mmHg at 25°C
Appearance	White solid
pKa	-0.89±0.10(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.544
MDL	MFCD04116913

21190-88-5 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36 - Irritating to the eyes
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

21190-88-5 - Introduction

acid ethyl ester is an organic compound with the chemical formula C8H8BrNO2. It is a colorless liquid with a special smell. The compound is soluble in organic solvents such as ethanol, dimethylformamide and benzene, and insoluble in water.

acid ethyl ester has a wide range of applications in organic synthesis. It can be used as a pharmaceutical intermediate for the synthesis of a wide range of drugs and bioactive molecules. In addition, it can also be used in the Gormperman reaction and palladium-catalyzed cross-coupling reactions in organic synthesis.

There are two common methods for acid ethyl ester:
1. It is obtained by the reaction of 6-bromopyridine and chloroacetate, and then hydrolyzed with alkali after the reaction.
2. By 6-bromopyridine and chloroacetic acid ester reaction, acid chloride, and then react with alcohol to obtain the product.

Safety precautions are required when using and storing acid ethyl ester. It is a flammable liquid and should be stored in a cool, well-ventilated place, away from fire and high temperatures. Appropriate protective equipment, such as lab gloves and goggles, should be worn during operation. If ingestion or contact with skin or eyes, rinse immediately with plenty of water and seek medical help.

Last Update：2024-04-09 20:52:54