212844-54-7

212844-54-7

(2R)-2-[[6-[(3-CHLORO-4-CARBOXYPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL

CAS: 212844-54-7

Molecular Formula: C20H25ClN6O3

212844-54-7 - Names and Identifiers

Name	(2R)-2-[[6-[(3-CHLORO-4-CARBOXYPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL
Synonyms	NG 95 PURVALANOL B Purvalanol B(NG 95) Purvalanol B ( NG 95) (R)-2-Chloro-4-((2-((1-hydroxy-3-methylbutan-2-yl)amino)-9-isopropyl-9H-purin-6-yl)amino)benzo (2R)-2-((6-((3-Chloro-4-carboxyphenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol (2R)-2-[[6-[(3-CHLORO-4-CARBOXYPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL NG 95, (2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
CAS	212844-54-7
InChIKey	ZKDXRFMOHZVXSG-HNNXBMFYSA-N

212844-54-7 - Physico-chemical Properties

Molecular Formula	C20H25ClN6O3
Molar Mass	432.9
Density	1.43±0.1 g/cm3(Predicted)
Melting Point	58.5 °C
Boling Point	660.6±65.0 °C(Predicted)
Solubility	DMSO: 37mg/mL, soluble
Appearance	solid
pKa	2.81±0.25(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Store in freezer, under -20°C

212844-54-7 - Risk and Safety

WGK Germany

3

212844-54-7 - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	2.31 ml	11.55 ml	23.1 ml
5 mM	0.462 ml	2.31 ml	4.62 ml
10 mM	0.231 ml	1.155 ml	2.31 ml
5 mM	0.046 ml	0.231 ml	0.462 ml

Last Update：2024-01-02 23:10:35

212844-54-7 - Reference Information

biological activity	Purvalanol B (NG-95) is an effective and selective inhibitor of cyclin-dependent kinase (CDK), and its IC50 values for cdc2-cyclin B, CDK2-cyclin A, CDK2-cyclin E and CDK5-p35 are 6 nM, 6 nM, 9 nM and 6 nM respectively.
target	TargetValue cdc2-cyclin B (Cell-Free Assay) 6 nM CDK2-Cyclin A (Cell-Free Assay) 6 nM CDK5-P35 (Cell-Free Assay) 6 nM CDK2-Cyclin E (Cell-Free Assay) 9 nM
Target	Value
cdc2-cyclin B (Cell-free assay)	6 nM
CDK2-Cyclin A (Cell-free assay)	6 nM
CDK5-P35 (Cell-free assay)	6 nM
CDK2-Cyclin E (Cell-free assay)	9 nM

Last Update：2024-04-10 22:29:15

212844-54-7

Shanghai Yuanye Bio-Technology Co., Ltd.

Product Name: (2R)-2-[[6-[(3-CHLORO-4-CARBOXYPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL Visit Supplier Webpage Request for quotation
CAS: 212844-54-7
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Shanghai Yuanye Bio-Technology Co., Ltd.

Product Name: (2R)-2-[[6-[(3-CHLORO-4-CARBOXYPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL Visit Supplier Webpage Request for quotation
CAS: 212844-54-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Click to send a QQ message

Wechat: 18301782025

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212844-54-7

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