2131184-57-9
VU0661013
CAS: 2131184-57-9
Molecular Formula: C39H39Cl2N5O4
2131184-57-9 - Names and Identifiers
2131184-57-9 - Physico-chemical Properties
| Molecular Formula | C39H39Cl2N5O4 |
| Molar Mass | 712.66 |
| Density | 1.37±0.1 g/cm3(Predicted) |
| Boling Point | 906.4±65.0 °C(Predicted) |
| pKa | 4.44±0.30(Predicted) |
| Storage Condition | 2-8℃ |
| Use | VU661013 is a potent MCL-1 selective inhibitor. |
2131184-57-9 - Reference Information
| biological activity | VU661013 is a new and effective selective MCL1 inhibitor. in TR-FRET analysis, the Ki value of human MCL-1 is 97±30 pM. However, the VU661013 does not significantly inhibit BCL-xL or BCL-2, and the corresponding Ki value is> 40 μM or = 0.73 μM. VU661013 can destroy the stability of BIM/MCL-1 combination and lead to apoptosis in AML. |
| target | TargetValue MCL1 (Cell-free say) 97 pM(Ki) |
| Target | Value |
| MCL1 (Cell-free assay) | 97 pM(Ki) |
Last Update：2024-04-09 22:09:11
