2138300-40-8
1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-
CAS: 2138300-40-8
Molecular Formula: C34H38N12O4
2138300-40-8 - Names and Identifiers
| Name | 1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- |
| Synonyms | STING agonist-4 STING AGONIST-4 1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- |
| CAS | 2138300-40-8 |
2138300-40-8 - Physico-chemical Properties
| Molecular Formula | C34H38N12O4 |
| Molar Mass | 678.74 |
| Density | 1.48±0.1 g/cm3(Predicted) |
| pKa | 11.97±0.43(Predicted) |
2138300-40-8 - References
| biological activity | STING agonist-4 is a stimulator of receptor agonists of the interferon gene (STING), its apparent inhibition constant IC50 is 20 nM, and STING agonist-4 is a compound containing two symmetrically related aminobenzimidazole (ABZI) groups. |
| Target | IC50: 20 nM (STING agnist -4) |
| Cell Line: | Human peripheral blood mononuclear cells (PBMCs) |
| Concentration: | 0.3 μM, 1 μM, 3 μM, 10 μM and 30 μM |
| Incubation Time: | 2 hours |
| Result: | Caused phosphorylation of IRF3 and STING and induced secretion of IFN-β. |
Last Update：2024-04-09 20:52:54
