Name | Palmitoyl pentapeptide |
Synonyms | Palmitoyl pentapeptide PalMitoyl Pentapeptide-4 Matrixyl,Palmitoyl pentapeptide-4 Matrixyl (Palmitoyl Pentapeptide) |
CAS | 214047-00-4 |
EINECS | 606-757-9 |
Molecular Formula | C{39}H{75}N{7}O{10} |
Molar Mass | 802.05 |
Density | 1.147 |
Boling Point | 1120.1±65.0 °C(Predicted) |
Storage Condition | 2-8℃ |
Use | Overview peptide (peptide) is a small molecule protein, also known as polypeptide or peptide, it is composed of a certain sequence of amino acids linked by amide bonds, two amino acids called dipeptide, three amino acids called three peptide, in turn. Peptides play an important role in the growth, development and metabolism of organisms. Almost all the physiological processes in the human body are regulated by polypeptides or proteins composed of specific amino acid sequences. In the process of skin natural aging and nursing, peptides play an important role in chemical book, such as cell proliferation, cell migration, inflammation, angiogenesis, pigment formation, protein synthesis and regulation. According to the survey, the most frequently used peptides by foreign famous brands are: palmitoyl pentapeptide -3 (pentapeptide), acetyl hexapeptide -3, acetyl tetrapeptide -5, palmitoyl oligopeptide (palmitoyl tripeptide -1), palmitoyl tetrapeptide -3 and carnosine, etc., these several beauty peptides are used by various brands of search results are more than 500, it is widely used. |
Abstract:
In this study, a Capillary electrophoresis (CE) method was established to analyze the common hexapeptides and pentapeptides in anti-old products. Peptide is a common active additive, but because it is expensive and there is no clear standard for determination, it is often inconsistent with the situation, so the establishment of its detection method is urgent. This method using sodium dodecyl sulfate surfactant and polyethylene glycol added to phosphate buffer solution, can simultaneously and rapidly analyze five different peptides, including palmitoyl pentapeptide-3 (PP3),pentapeptide-18 (PP18),acetyl hexapeptide-3 (AH3),pentapeptide-3 (PA3) and prezatide copper acetate (PCA); All analytes were completely separated within 15 minutes at the detection wavelength of 200 nm, and qualitative and quantitative analysis was performed. This method shows a good linear relationship (r = 0.996) after confirmation, and the detection limit of the analyte is as follows, PP3 and PCA were 2.5 μg/mL; PP18 was 0.8 μg/mL; AH3 and PA3 were 1.5 μg/mL. In the discussion of accuracy and precision, the relative standard deviation (RSD) and relative error (RE) are both less than 10.0%, showing good reproducibility and ideal accuracy. In addition, the method of this study has been successfully applied to the analysis of commercially available products, and it is expected that this method can be widely used in the detection and analysis of active ingredients in chemical products in the future, in order to ensure the rights and interests of manufacturers and consumers.
stowed
Key words:
capillary electrophoresis peptide care product Capilla electroporation peptides cosmetic
year:
2017
CN 02123046
application date:
Jun 11, 2002
Public/Announcement Number:
CN 1465586 A
applicant (patent):
Ruian Pharmaceutical Co., Ltd.
inventor:
Peng Shiqi , Zhao Ming , Wang Chao , Lina
National and provincial code:
Taiwan
Abstract:
The present invention relates to a cyclic peptide of the formula: cyclo(Xaa-Arg-Pro-Ala-Lys) wherein Xaa is Ala,Gly,Glu,Gln,Asp,Asn,Arg or Lys. The cyclic peptide of formula (I) of the present invention has a thrombolytic effect. The present invention also relates to a process for the preparation of a cyclic peptide of formula (I).
sovereignty:
1. A cyclic pentapeptide of formula (I): cyclo(Xaa-Arg-Pro-Ala-Iys) (I) where Xaa is Ala, Gly, Glu, Gln, Asp, Asn, Arg, or Lys.
Application (patent) number:
CN201710119698.2
applicant (patent):
Shanxi Jinbo Biological Medicine Co., Ltd.
inventor:
Abstract:
The invention discloses a biological maintenance toothpaste containing pentapeptide, comprising the following raw materials in weight percentages: pentapeptide 0.0001-0.002%, calcium carbonate 30-50%, glycerol 25-48%, sodium carboxymethyl cellulose 1~3%, sodium lauryl sulfate 1.8 ~ 3.2%, preservatives (one or more parabens) 0.1 ~ 0.8%, peppermint oil 1~2%, carrot extract 0.010.02%; The balance is water. The combined use of these components, especially the active ingredient five peptide and carrot extract, can promote the proliferation of collagen and indirectly repair the micro-damage of human oral mucosa. Five peptide anti-aging effect, can prevent and improve gingival atrophy. In addition, five peptide can promote hyaluronic acid and elastic fiber hyperplasia, can effectively activate the synthesis of hyaluronic acid, which is essential to maintain oral moisture, relieve dry mouth. The toothpaste has wide adaptability, good effect, and is safe and harmless.