21414-41-5

21414-41-5 - Names and Identifiers

Name	Glucoraphanin
Synonyms	Glucoraphanin GLUCORAPHANIN GLUCORAPHANIN POTASSIUM SALT(P) GLUCORAPHANIN POTASSIUM SALT(SH) GLUCORAPHANIN POTASSIUM SALT(RG) 4-METHYLSULFINYLBUTYLGLUCOSINOLATE 1-Thio-β-D-glucopyranose 1-[N-(hydroxysulfonyloxy)-5-methylsulfinylpentanimidate] 1-Thio-β-D-glucopyranose 1-[N-(hydroxysulfonyloxy)-5-(methylsulfinyl)pentanimidate] N-(Hydroxysulfonyloxy)-5-(methylsulfinyl)pentanimidothioic acid β-D-glucopyranosyl ester
CAS	21414-41-5

21414-41-5 - Physico-chemical Properties

Molecular Formula	C12H23NO10S3
Molar Mass	437.51
Density	1.78±0.1 g/cm3 (20 ºC 760 Torr)
Solubility	Soluble in water, methanol, DMSO
Appearance	White powder
pKa	-2.93±0.18(Predicted)
Storage Condition	2-8°C
MDL	MFCD08460269
Physical and Chemical Properties	White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from semen raphani.
In vivo study	Glucoraphanin reduces weight gain and increases energy expenditure in HFD-fed mice. Glucoraphanin can improves insulin sensitivity and glucose tolerance in HFD-fed mice. However, Glucoraphanin does not exert antiobesity and insulin-sensitizing effects in Nrf2 −/− Mice. Glucoraphanin blocks HFD-induced reduction of Ucp1 protein levels in white adipose depots of wild-type mice but not in Nrf2 −/− mice. Glucoraphanin alleviates HFD-induced hepatic steatosis and oxidative stress. Glucoraphanin suppresses HFD-induced proinflammatory activation of macrophages in liver and adipose tissue. Glucoraphanin also decreases circulating LPS and the relative abundance of proteobacteria in the gut microbiomes of HFD-fed mice. Mice with pellets including 0.1% Glucoraphanin (GF) significantly attenuates the decreased social avoidance time in stressed mice. In the 1% sucrose preference test (SPT), treatment with pellets including 0.1% GF significantly attenuates the decreased sucrose preference of stressed mice.

21414-41-5 - Reference

Reference

1. Jiang Rui, Li Hongyan, Xue Changhu. Effects of different treatments on sulforaphane and sulforaphane in semen raphani [J]. Food Science and Technology 2019 v.44;No.337(11):91-97.
2. Zhang Rui, Yu Jianli, Song Xuan, Yan Yuanyuan, Li Chao. Antibacterial activity and in vitro immune activity of sulfatide extract from broccoli and Raphanus sativus [J]. Food Research and Development, 2021,42(04):1-7.

21414-41-5 - Reference Information

Introduction	sulforaphane Glucosinolate is an active ingredient of broccoli extract and a prodrug of sulforaphane, sulforaphane Glucosinolates can be converted into sulforaphane in vivo, thereby exerting anti-cancer and anti-oxidation effects.
efficacy and function	sulforaphane glucosinolates are a naturally active product mainly found in Broccoli seeds and shoots, after the action of myrosinase or intestinal microorganisms can be converted into Sulforaphane (Sulforaphane). Sulforaphane is one of the most potent activators of Nrf2, which can activate Nrf2 to activate detoxification, antioxidant, anti-inflammatory and other cell protective effects.
biological activity	Glucoraphanin is glucosinolates present in cruciferous vegetables and is a precursor of the Nrf2 inducer sulforaphane, the latter has antioxidant, anti-inflammatory, anti-cancer effects.
Use	Anti-cancer antioxidant. for content determination/identification/pharmacological experiments.

Last Update：2024-04-09 21:01:54