2158197-70-5
HS1371
CAS: 2158197-70-5
Molecular Formula: C24H24N4O
2158197-70-5 - Names and Identifiers
| Name | HS1371 |
| Synonyms | HS1371 HS1371 HS-1371 CS-2831 HS 1371 2158197-70-5 Quinoline, 4-(4-methylphenoxy)-7-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- |
| CAS | 2158197-70-5 |
2158197-70-5 - Physico-chemical Properties
| Molecular Formula | C24H24N4O |
| Molar Mass | 384.47 |
| Solubility | DMSO : 16.67 mg/mL (43.36 mM; Need ultrasonic) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Use | HS-1371 is a novel kinase inhibitor of RIP3-mediated necroptosis. HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner, providing a mechanism of action. Moreover, the compound inhibited TNF-induced necroptosis but did not inhibit TNF-induced apoptosis, indicating that this novel inhibitor has a specific inhibitory effect on RIP3-mediated necroptosis via the suppression of RIP3 kinase activity. HS-1371 could serve as a potential preventive or therapeutic agent for diseases involving RIP3 hyperactivation. |
| In vitro study | HS-1371 has an inhibitory effect on the phosphorylation of RIP3 in the S227 site. In HT-29 cells, it had complete inhibitory activity on TNF-induced necroptosis signals and no activity on phosphorylation of RIP3 and MLKL. The formation of the necrosis complex can be prevented by HS-1371 inhibition of RIP3 kinase activity, disrupting the recruitment of MLKL. TNF-induced cell necrosis was rescued by HS-1371. It protects cells from rip3-dependent necrotic cell death, but does not affect apoptotic cell death. |
2158197-70-5 - Reference
| Reference Show more | 1. Park HH, et al. HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis. Exp Mol Med. 2018 Sep 20;50(9):125 |
2158197-70-5 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.601 ml | 13.005 ml | 26.01 ml |
| 5 mM | 0.52 ml | 2.601 ml | 5.202 ml |
| 10 mM | 0.26 ml | 1.3 ml | 2.601 ml |
| 5 mM | 0.052 ml | 0.26 ml | 0.52 ml |
Last Update：2024-01-02 23:10:35
2158197-70-5 - Introduction
HS1371 is an organic compound, its chemical name is 2-methacrylic acid 4-sulfonic acid O-phenylenediamine. The following is an introduction to the nature, use, formulation and safety information of HS1371:
Nature:
HS1371 is a colorless crystalline solid with good solubility. It has high solubility in water and low solubility in organic solvents.
Use:
HS1371 is mainly used as an intermediate for dyes and pigments, and has a wide range of applications in the chemical industry. It can be used in textile dyes, pigments, inks, coatings and other fields.
Preparation Method:
The preparation method of HS1371 is generally obtained by reacting O-Phenylenediamine and 2-methacrylic acid. First, O-Phenylenediamine and purified 2-methacrylic acid are reacted in an appropriate solvent, and then a sulfonating agent is added to carry out a sulfonation reaction to obtain the product hs1371. The specific preparation method generally needs to be carried out under suitable reaction conditions, and the reaction conditions such as temperature and pH value need to be strictly controlled.
Safety Information:
HS1371 is an organic compound that is irritating and corrosive. When handling and using the compound, it is recommended to take appropriate experimental procedures and protective measures, such as wearing protective gloves and masks, to avoid direct contact with skin and eyes. During the treatment, care should be taken to avoid inhalation of its volatiles or dust. At the same time, be sure to store the compound properly and place it in a cool, dry and well-ventilated place, avoiding contact with oxidants, acids and alkalis to prevent possible dangerous situations. Please refer to the material safety data sheet of the compound before use and follow the correct practice.
Nature:
HS1371 is a colorless crystalline solid with good solubility. It has high solubility in water and low solubility in organic solvents.
Use:
HS1371 is mainly used as an intermediate for dyes and pigments, and has a wide range of applications in the chemical industry. It can be used in textile dyes, pigments, inks, coatings and other fields.
Preparation Method:
The preparation method of HS1371 is generally obtained by reacting O-Phenylenediamine and 2-methacrylic acid. First, O-Phenylenediamine and purified 2-methacrylic acid are reacted in an appropriate solvent, and then a sulfonating agent is added to carry out a sulfonation reaction to obtain the product hs1371. The specific preparation method generally needs to be carried out under suitable reaction conditions, and the reaction conditions such as temperature and pH value need to be strictly controlled.
Safety Information:
HS1371 is an organic compound that is irritating and corrosive. When handling and using the compound, it is recommended to take appropriate experimental procedures and protective measures, such as wearing protective gloves and masks, to avoid direct contact with skin and eyes. During the treatment, care should be taken to avoid inhalation of its volatiles or dust. At the same time, be sure to store the compound properly and place it in a cool, dry and well-ventilated place, avoiding contact with oxidants, acids and alkalis to prevent possible dangerous situations. Please refer to the material safety data sheet of the compound before use and follow the correct practice.
Last Update：2024-04-09 21:11:58
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Spot supply
Product Name: HS1371 Visit Supplier Webpage Request for quotationCAS: 2158197-70-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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