216309-28-3

216309-28-3 - Names and Identifiers

Name	5-[(Trimethylsilyl)ethynyl]pyrimidine
Synonyms	5-(2-TMS-ethynyl)pyrimidine 5-trimethylsilanylethynyl-pyrimidine 5-[(Trimethylsilyl)ethynyl]pyrimidine 5-((Trimethylsilyl)ethynyl)pyrimidine pyrimidine, 5-[2-(trimethylsilyl)ethynyl]- Pyrimidine, 5-[2-(trimethylsilyl)ethynyl]-
CAS	216309-28-3
InChI	InChI=1/C9H12N2Si/c1-12(2,3)5-4-9-6-10-8-11-7-9/h6-8H,1-3H3

216309-28-3 - Physico-chemical Properties

Molecular Formula	C9H12N2Si
Molar Mass	176.29
Density	0.99±0.1 g/cm3(Predicted)
Boling Point	223.5±22.0 °C(Predicted)
Flash Point	88.9°C
Vapor Presure	0.143mmHg at 25°C
pKa	1.98±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.502

216309-28-3 - Risk and Safety

WGK Germany

216309-28-3 - Introduction

5-[(Trimethylsilyl)ethynyl]pyrimidine is an organic compound with the chemical formula C10H13N3Si. The following is information about the properties, use, preparation and safety of the compound:

Nature:
1. Appearance: 5-[(Trimethylsilyl)ethynyl]pyrimidine is a white crystalline solid.
2. Solubility: It has good solubility in common organic solvents such as ether, chloroform and dichloromethane.
3. Melting point: The melting point of this compound is about 68-70 degrees Celsius.

Use:
1. Synthesis of pyrimidine derivatives: 5-[(Trimethylsilyl)ethynyl]pyrimidine can be used as an important intermediate for the synthesis of bioactive pyrimidine derivatives.
2. Pharmaceutical Research: Due to its ability to interact with nitrogen bases, 5-[(Trimethylsilyl)ethynyl]pyrimidine is widely used in the field of pharmaceutical research for the design and synthesis of biologically active compounds.

Method:
The preparation of 5-[(Trimethylsilyl)ethynyl]pyrimidine is mainly carried out by the following steps:
1. REACTION: trimethylsilyl vinyl chloride and isocyanate react under the catalysis of alkali to generate Silicon hydrazone compound.
2. Cyclization reaction: the cyclization reaction between the silylhydrazone compound and 2-bromoacetylene generates 5-[(Trimethylsilyl)ethynyl]pyrimidine.

Safety Information:

Last Update：2024-04-09 02:00:44