218600-53-4
2-Cyano-3,12-dioxoolean-1,9(11)-dien-28-oic acid methyl ester
CAS: 218600-53-4
Molecular Formula: C32H43NO4
218600-53-4 - Names and Identifiers
| Name | 2-Cyano-3,12-dioxoolean-1,9(11)-dien-28-oic acid methyl ester |
| Synonyms | TP155 TP-155 TP-155 RTA402 CDDOME TP 155 TP-155C CDDO-Me RTA-402 RTA 402 NSC 713200 NSC 713200 CDDO-METHYL ESTER BARDOXOLONE METHYL CDDO METHYL ESTER Bardoxolone Me ester Bardoxolone Methyl (RTA 402) methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate 2-Cyano-3,12-dioxoolean-1,9(11)-dien-28-oic acid methyl ester Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, methyl ester Methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester (6aR,6bS,8aR,12aS,14aR,14bS)-11-Cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydropicene-4a(2H)-carboxylic acid methyl ester |
| CAS | 218600-53-4 |
| EINECS | 606-850-4 |
| InChI | InChI=1/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1 |
218600-53-4 - Physico-chemical Properties
| Molecular Formula | C32H43NO4 |
| Molar Mass | 505.69 |
| Density | 1.15 |
| Melting Point | 215-223°C |
| Boling Point | 600.8±55.0 °C(Predicted) |
| Flash Point | 256.5°C |
| Solubility | Soluble in DMSO, not in water |
| Vapor Presure | 2.15E-14mmHg at 25°C |
| Appearance | White to off-white solid powder |
| Color | White to Light Brown |
| Storage Condition | Refrigerator |
| Refractive Index | 1.558 |
| MDL | MFCD11983137 |
| In vitro study | Bardoxolone Methyl acts on mouse macrophages and has a strong inhibitory activity on the production of nitric oxide induced by interferon, with an IC50 of 0.1 nM. Bardoxolone Methyl reduced the viability of leukemia HL-60,KG-1, and NB4 cells with IC50 of 0.4,0.4, and 0.27 μm, respectively. CDDO-ME induces pro-apoptotic Bax protein expression, inhibits the activation of ERK1/2, and it inhibits the phosphorylation of Bcl-2, which contributes to the induction of apoptosis. Bardoxolone Methyl potently inhibits (IL)-1beta, phorbol ester, okadaic acid, hydrogen peroxide, lipopolysacchar, and cigarette smoke activation of constitutive and inducible NF-κB tumor necrosis factor. |
| In vivo study | Bardoxolone Methyl(60 mg/kg), administered in vivo, reduces the number, size and severity of lung tumors. Bardoxolone Methyl can also significantly reduce the response of in vivo inflammatory factors stimulated by LPS, induce the expression of HO-1 protein in spleen, and protect mice against lethal doses of LPS. |
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Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: RTA-402 Visit Supplier Webpage Request for quotationCAS: 218600-53-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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