2195-44-0
2-bromo-N-(4-fluorophenyl)acetamide
CAS: 2195-44-0
Molecular Formula: C8H7BrFNO
2195-44-0 - Names and Identifiers
| Name | 2-bromo-N-(4-fluorophenyl)acetamide |
| Synonyms | CHEMBRDG-BB 4023666 2-bromo-N-(4-fluorophenyl)acetamide 2-bromo-N-(4-fluorophenyl)ethanamide 2-BROMO-N-(4-FLUORO-PHENYL)-ACETAMIDE Acetamide, N-(4-fluorophenyl)-2-bromo- acetamide, 2-bromo-N-(4-fluorophenyl)- |
| CAS | 2195-44-0 |
| InChI | InChI=1/C8H7BrFNO/c9-5-8(12)11-7-3-1-6(10)2-4-7/h1-4H,5H2,(H,11,12) |
2195-44-0 - Physico-chemical Properties
| Molecular Formula | C8H7BrFNO |
| Molar Mass | 232.05 |
| Density | 1.658±0.06 g/cm3(Predicted) |
| Melting Point | 137-138 °C |
| Boling Point | 349.5±27.0 °C(Predicted) |
| Flash Point | 165.2°C |
| Vapor Presure | 4.69E-05mmHg at 25°C |
| pKa | 11.51±0.70(Predicted) |
| Refractive Index | 1.606 |
2195-44-0 - Risk and Safety
| Hazard Class | IRRITANT |
2195-44-0 - Introduction
2-bromo-N-(4-fluorophenyl)acetamide is an organic compound with the chemical formula C8H8BrNO and a molecular weight of 215.06. The following is a description of the properties, uses, preparation and safety information of the compound:
1. Nature:
-Appearance: In the form of colorless crystals.
-Melting point: About 115-119 ℃.
-Solubility: Soluble in a variety of organic solvents, such as ethanol, dimethylformamide and dichloromethane.
-Stability: This compound is relatively stable at room temperature.
2. Use:
-Chemical intermediate: 2-bromo-N-(4-fluorophenyl)acetamide is an intermediate for the synthesis of organic compounds and can be used in important steps in organic synthesis reactions.
-Pharmaceutical research: The compound may be used in the field of drug development, for example, as a lead compound for antibacterial drugs.
3. Preparation method:
The preparation of 2-bromo-N-(4-fluorophenyl)acetamide can be carried out by the following steps:
(1) 4-fluorobenzamide and bromoacetic acid were transesterified to obtain 4-fluorophenyl Acetyl bromide.
(2) React 4-fluorophenylacetyl bromide with sodium bromide dispersed in ethanol to generate 2-bromo-N-(4-fluorophenyl)acetamide.
(3) The product was crystallized or purified to obtain pure 2-bromo-N-(4-fluorophenyl)acetamide crystals.
4. Safety Information:
2-bromo-N-(4-fluorophenyl)acetamide is relatively safe under correct use and storage conditions, but the following matters still need to be noted:
-The compound may be irritating to the eyes and skin, and should avoid contact with the body when in contact. In case of contact, flush the affected area immediately with plenty of water and seek medical help immediately.
-Wear appropriate protective gloves and goggles when handling the compound.
-The compound should be stored in a dry, cool, well-ventilated place, away from flammable materials and oxidizing agents.
-When handling or disposing of waste, comply with appropriate regulations and safety practices.
1. Nature:
-Appearance: In the form of colorless crystals.
-Melting point: About 115-119 ℃.
-Solubility: Soluble in a variety of organic solvents, such as ethanol, dimethylformamide and dichloromethane.
-Stability: This compound is relatively stable at room temperature.
2. Use:
-Chemical intermediate: 2-bromo-N-(4-fluorophenyl)acetamide is an intermediate for the synthesis of organic compounds and can be used in important steps in organic synthesis reactions.
-Pharmaceutical research: The compound may be used in the field of drug development, for example, as a lead compound for antibacterial drugs.
3. Preparation method:
The preparation of 2-bromo-N-(4-fluorophenyl)acetamide can be carried out by the following steps:
(1) 4-fluorobenzamide and bromoacetic acid were transesterified to obtain 4-fluorophenyl Acetyl bromide.
(2) React 4-fluorophenylacetyl bromide with sodium bromide dispersed in ethanol to generate 2-bromo-N-(4-fluorophenyl)acetamide.
(3) The product was crystallized or purified to obtain pure 2-bromo-N-(4-fluorophenyl)acetamide crystals.
4. Safety Information:
2-bromo-N-(4-fluorophenyl)acetamide is relatively safe under correct use and storage conditions, but the following matters still need to be noted:
-The compound may be irritating to the eyes and skin, and should avoid contact with the body when in contact. In case of contact, flush the affected area immediately with plenty of water and seek medical help immediately.
-Wear appropriate protective gloves and goggles when handling the compound.
-The compound should be stored in a dry, cool, well-ventilated place, away from flammable materials and oxidizing agents.
-When handling or disposing of waste, comply with appropriate regulations and safety practices.
Last Update：2024-04-09 15:17:55
