220227-37-2 - Names and Identifiers
Name | 3,4,5-trifluorobenzyl alcohol
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Synonyms | RARECHEM AL BD 0343 3,4,5-TRIFLUOROBENZYL ALCOHOL 3,4,5-trifluorobenzyl alcohol 3,4,5-Trifluorobenzoyl alcohol 3,4,5-trifluorobenzenemethanol (3,4,5-trifluorophenyl)methanol 3,4,5-TRIFLUORO BENZENEMETHANOL (3,4,5-trifluorophenyl)Methanol Benzenemethanol, 3,4,5-trifluoro- Benzenemethanol, 3,4,5-trifluoro- (9CI)
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CAS | 220227-37-2
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EINECS | 642-879-9 |
InChI | InChI=1/C7H5F3O/c8-5-1-4(3-11)2-6(9)7(5)10/h1-2,11H,3H2 |
220227-37-2 - Physico-chemical Properties
Molecular Formula | C7H5F3O
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Molar Mass | 162.11 |
Density | 1.385g/mLat 25°C(lit.) |
Boling Point | 203-204°C760mm Hg(lit.) |
Flash Point | 210°F |
Water Solubility | Soluble in water 100 g/L. |
Vapor Presure | 0.313mmHg at 25°C |
BRN | 8681069 |
Storage Condition | Room Temprature |
Refractive Index | n20/D 1.4700(lit.) |
MDL | MFCD00083527 |
220227-37-2 - Risk and Safety
Hazard Symbols | Xi - Irritant

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Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin.
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Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
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WGK Germany | 3 |
HS Code | 29062990 |
Hazard Class | IRRITANT |
220227-37-2 - Introduction
3,4,5-trifluorobenzyl alcohol is an organic compound with the chemical formula C7H5F3O. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: colorless liquid
-Boiling point: 163-165 ° C
-Density: 1.47g/cm³
-Melting point:-18 ℃
-Solubility: Soluble in water and common organic solvents, such as ethanol and ether.
Use:
3,4,5-trifluorobenzyl alcohol is widely used in organic synthesis and pharmaceutical fields. Common applications include:
-As an intermediate or raw material, it participates in organic synthesis reactions, such as alcohol etherification reactions or fluorination reactions in organic synthesis.
-Used as a precursor compound for fluorescent dyes.
Method:
3,4,5-trifluorobenzyl alcohol can be prepared:
-p-Trifluoromethylphenol reacts with anhydrous copper chloride to generate p-trifluoromethylphenylimine. The trifluoromethylphenylimine is then reduced to 3,4,5-trifluorobenzyl alcohol by a reduction reaction.
Safety Information:
- 3,4,5-trifluorobenzyl alcohol is irritating to the skin and eyes. After contact, the corresponding part should be rinsed thoroughly with water immediately.
-Wear appropriate personal protective equipment such as gloves, goggles and protective clothing during operation.
-should be in a well ventilated place to operate, avoid inhalation of vapor.
-should be stored in a cool, dry, ventilated place, away from fire and oxidant.
Last Update:2024-04-10 22:29:15