22255-40-9
[1S-(1α,4aα,6α,7α,7aα)]-1-(β-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methylcyclopenta[c]pyran-4-carboxylic acid
CAS: 22255-40-9
Molecular Formula: C16H24O10
22255-40-9 - Names and Identifiers
22255-40-9 - Physico-chemical Properties
| Molecular Formula | C16H24O10 |
| Molar Mass | 376.36 |
| Density | 1.60±0.1 g/cm3(Predicted) |
| Melting Point | 168°C |
| Boling Point | 646.3±55.0 °C(Predicted) |
| Specific Rotation(α) | (c, 0.5 in H2O)-86.2 |
| Flash Point | 235.5°C |
| Solubility | Soluble in water, methanol, ethanol, acetone, DMSO and other solvents. |
| Vapor Presure | 1.97E-19mmHg at 25°C |
| Appearance | White powder |
| pKa | 4.55±0.70(Predicted) |
| Storage Condition | -20°C |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.633 |
| MDL | MFCD00017417 |
| Physical and Chemical Properties | White-like crystalline powder, soluble in methanol, derived from Gentiana macrophylla. |
22255-40-9 - Risk and Safety
| WGK Germany | 3 |
22255-40-9 - Reference
| Reference Show more | 1. Liu Qian, Zhang Minmin, Li Shengbo et al. Determination of Chemical Constituents in Buds and Leaves of Honeysuckle in Tibet Production Areas by HPLC-DAD Method [J]. Shandong Science 2018 031(004):20-25. 2. Zhang Yu, Yang Jian, Qin Zhenxian et al. UPLC Determination of Terpene Constituents in Honeysuckle from Different Production Areas [J]. 2016 of Traditional Chinese Medicine 39(009):2053-2055. 3. Zhang Yu, yang Jian, Qin Zhenxian, et al. Process Optimization for Enrichment of Cycloether Terpene Glycosides from Honeysuckle with Macroporous Adsorption Resin [J]. Chinese Journal of Experimental Prescriptions, 2016(24):18-21. 4. Wu Xinyi, Liu Xiuzhang, Qu Yunhui, et al. Box-Behnken Design-Response Surface Methodology to Optimize Primary Processing Technology of Gentiana Yunnan [J]. ISTIC PKU CA 2020, Page 1830-1835, Volume 31, Volume 15, China Pharmacy, 202020. 5. Zhang Minmin, Liu Daicheng, Wang Daijie, etc. SPME-GC/MS joint HSDE-HPLC-DAD analysis and characterization of main chemical components in new honeysuckle varieties [J]. natural product research and development, 2016, 028(009):1390-1396,1413. 6. ma yun, Wang yaoyao, Wang lei, et al. changes in morphology and content of 13 active components during honeysuckle development [J]. traditional Chinese medicine, 2018, 041(007):1559-1565. 7. Zhu Heng, Yu Jinqian, Liu Qian, et al. Multi-index Quantitative Fingerprint Analysis of Shandong Honeysuckle Based on RRLC-DAD-ESI-Q-TOF-MS Technology [J]. Chinese Journal of Experimental Prescriptions, 2017, 023(019):82-89. 8. Wu Xinyi, Liu Xiuzhen, Qu Yunhui, Shi Pingping, Yang Yan, Li Zhimin, Tian Hao, Gu Liping. Box-Behnken Design-Response Surface Methodology to Optimize Primary Processing Technology of Gentiana yunnanensis [J]. Chinese pharmacy, 2020,31(15):1830-1835. 9. Tao, Yi, et al. "Integrating UHPLC-MS/MS quantification and DAS analysis to investigate the effects of wine-processing on the issue distributions of bioactive constituents of herbs in rats: Exemplarily show for Dipsacus asper." Journal of Chromatography 10. Hengqiang Zhao, Changjiangsheng Lai, Minmin Zhang, Siduo Zhou, qian Liu, Daijie Wang, Yanling Geng, Xiao Wang,An improved 2D-HPLC-UF-ESI-TOF/MS approach for enrichment and comprehensive characterization of minor neuraminidase inhibitors from Flos Lonicera 11. Hengqiang Zhao, Changjiangsheng Lai, Minmin Zhang, Siduo Zhou, Qian Liu, Daijie Wang, Yanling Geng, Xiao Wang, an improved 2D-HPLC-UF-ESI-TOF/MS approach for enrichment and comprehensive characterization of minor neuraminidase inhibitors from Flos Lonicera 12. [IF = 4.759] Wenhua Ji et al. "Water-compatible micron-sized monodisperse molecularly imprinted beats for selective extraction of five iridoid glycosides from Cornus officinalis fructus." J Chromatogr A. 2017 Jun;1504:1 13. [IF = 4.142] Wang Chenxi et al. "Systematic quality evaluation of Peiyuan Tongnao capsule by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry and adjusted parallel reaction monitoring of quality markers." Anal Bioanal Chem. 2019 Nov;4 14. [IF = 3.935] Hengqiang Zhao et al. "An improved 2D-HPLC-UF-ESI-TOF/MS approach for enrichment and comprehensive characterization of minor neuraminidase inhibitors from Flos Lonicerae Japonicae." J Pharmaceut Biomed. 2019 Oct;175:112758 15. [IF = 3] Hui-Qin PAN et al. "Plant metabolomics for studying the effect of two insecticides on comprehensive constituents of Lonicerae Japonicae Flos." Chin J Nat Medicines. 2021 Jan;19:70 16. [IF = 1.902] Huan Liu et al. "A new and effective evaluation method for Radix Gentianae Macrophyllae herbs based on 2-phenylethyl β-d-glycopyranoside, 2-methoxyanofinic acid and gentioxepine by UPLC-QTOF-MS exploring and HPLC-DAD quantification." Biomed Chromatogr 2021 |
22255-40-9 - Reference Information
| overview | loganic acid (dzylic acid) is an iridoid glycoside isolated from the rhizome of Gentianaceae Gentiana. The purity is as high as 98.4%, and its character is pure white powder, hygroscopic, easily soluble in methanol and water. At present, the pharmacological studies of Gentiana macrophylla iridoid glycosides are mostly in the aspect of total glycosides, and the studies on loganic acid alone are relatively few. |
| application | loganolic acid is used as the medicinal active ingredient of Gentiana macrophylla, and is applied to drugs such as goufengding tablets and gust xiaotong capsules. |
| biological activity | Loganic acid is an iridoid isolated from dogwood fruit. Loganic acid can regulate atherosclerosis and redox state caused by diet. Loganic acid has strong free radical scavenging activity and has significant cytoprotective effect on heavy metal-mediated toxicity. |
| chemical properties | white crystalline powder, soluble in methanol, derived from Gentiana macrophylla. |
| use | loganic acid has the effect of clearing heat and drying dampness. used for content determination/identification/pharmacological experiment, etc. |
Last Update：2024-04-09 21:21:28
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Product Name: Loganic Acid Visit Supplier Webpage Request for quotationCAS: 22255-40-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Loganic acid Visit Supplier Webpage Request for quotationCAS: 22255-40-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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