22356-80-5
2-hydroxy-4-methylbenzenesulphonic acid
CAS: 22356-80-5
Molecular Formula: C7H8O4S
22356-80-5 - Names and Identifiers
22356-80-5 - Physico-chemical Properties
| Molecular Formula | C7H8O4S |
| Molar Mass | 188.2 |
| Density | 1.482±0.06 g/cm3(Predicted) |
| Melting Point | 97 °C - 100 °C |
| Solubility | Methanol (Slightly), Water (Slightly) |
| Appearance | Solid |
| Color | Off-White to Pale Yellow |
| pKa | -0.43±0.50(Predicted) |
| Storage Condition | Hygroscopic, Refrigerator, under inert atmosphere |
| Physical and Chemical Properties | This product is a calcium salt of cresol sulfonic acid (C7H8O4S), white powder, easily soluble in water. Cresol sulfonic acid is a needle crystal with a melting point of 109-110°C. |
22356-80-5 - References
| Overview | calcium cresol sulfonate is a white crystalline powder, easily soluble in water. From m-cresol by sulfonation, the formation of p-sulphonyl m-cresol, and calcium carbonate salt prepared. Expectorant Cough Medicine. Commonly used in the treatment of chronic bronchitis, the dosage is large, the effect is poor. Calcium cresol sulfonate is widely used as an antitussive agent, which is usually contained in commercial cough medicines. However, there is a lack of literature on manufacturing methods, specifications, pharmacology and therapeutic value. A number of samples were collected from commercially available APIs and analyzed and found to vary widely, e.g., from 4.5 to 13.5 calcium and less consistently sulfur. |
| Use | This product has expectorant and antitussive effects, and can be used to treat chronic bronchitis. |
| production method | cresol sulfonic acid (2-hydroxy-4-methylbenzenesulfonic acid) is obtained from m-cresol by sulfonation, and then with calcium carbonate salt. The sulfonation of m-cresol with sulfuric acid was carried out at 70-90 °c for 2 hours, at 95-105 °c for 3.5 hours, and then reacted with calcium carbonate to form a salt at 55-65 °c to give calcium cresol sulfonate. |
Last Update：2024-04-09 19:05:23
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Spot supply
Product Name: Policresulen Impurity 1 Visit Supplier Webpage Request for quotationCAS: 22356-80-5
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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