2247894-32-0
SGC-AAK1-1
CAS: 2247894-32-0
Molecular Formula: C21H25N5O3S
2247894-32-0 - Names and Identifiers
| Name | SGC-AAK1-1 |
| Synonyms | SGC-AAK1-1 SGC AAK1 1 AAK1 inhibitor 1 Cyclopropanecarboxamide, N-[6-[3-[[(diethylamino)sulfonyl]amino]phenyl]-1H-indazol-3-yl]- |
| CAS | 2247894-32-0 |
2247894-32-0 - Physico-chemical Properties
| Molecular Formula | C21H25N5O3S |
| Molar Mass | 427.52 |
| Density | 1.424±0.06 g/cm3(Predicted) |
| Solubility | Soluble in DMSO |
| pKa | 7.30±0.50(Predicted) |
| Storage Condition | -20℃ |
| Use | SGC-AAK1-1, a chemical probe, is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor. It also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1. |
| Target | IC50: 270 nM (AAK1). Ki: 9 nM (AAK1) |
2247894-32-0 - Reference
| Reference Show more | 1: Agajanian MJ, Walker MP, Axtman AD, et al. WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Cell Rep. 2019;26(1):79-93.e8. doi:10.1016/j.celrep.2018.12.023 |
2247894-32-0 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.339 ml | 11.695 ml | 23.391 ml |
| 5 mM | 0.468 ml | 2.339 ml | 4.678 ml |
| 10 mM | 0.234 ml | 1.17 ml | 2.339 ml |
| 5 mM | 0.047 ml | 0.234 ml | 0.468 ml |
Last Update：2024-01-02 23:10:35
Supplier List
Spot supply
Product Name: SGC-AAK1-1 Visit Supplier Webpage Request for quotationCAS: 2247894-32-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: SGC-AAK1-1 Visit Supplier Webpage Request for quotationCAS: 2247894-32-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History