225110-25-8

Name	Falcarindiol
Synonyms	Falcarindiol 8S)-Falcarindiol (3R,8S)-Falcarindiol (+)-(3R,8S)-falcarindiol 3(R),8(S),9(Z)-Falcarindiol (3R,8S,Z)-Heptadeca-1,9-dien-4,6-diyne-3,8-diol (3R,8S,9Z)-1,9-Heptadecadiene-4,6-diyne-3,8-diol 1,9-Heptadecadiene-4,6-diyne-3,8-diol,(3R,8S,9Z)-
CAS	225110-25-8

Biological activity	Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound that exists in many plants in the Umbelliferae family. Falcarindiol can inhibit the expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6) and interleukin-1 beta (IL-1β) stimulated by LPS. Falcarindiol can weaken LPS-induced activation of JNK, ERK, STAT1 and STAT3 signaling molecules. Falnidamol is a pyrimidine compound with anticancer activity.
target	TargetValue iNOS () TNFα () IL-6 () IL-1β () JNK () click more
Target	Value
use	Falcarindiol was isolated as an algicidal principle against the harmful red tide dinoflagellate, Heterocapsa circularisquama, from Notopterygii Rhizoma through bioassay-guided separation.To determine the ambiguous absolute structure of this active principle, all three stereoisomers as well as falcarindiol were synthesized. listen to as a result of intensive analytical of their physicochemical properties, T he configuration of Falcarinfiol was revealed to be 3R,8S. hearing (3S,8S)- and (3S,8R)-isomers were found to exhibit more potent algicidal activity than (3R,8S)-Falcarindiol isolated from Notopterygii Rhizo ma. for content determination/identification/pharmacological experiments, etc.

Last Update：2024-04-09 21:04:16

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CAS: 225110-25-8
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QQ: 3008007409

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225110-25-8

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